Association of anti-ribosomal P protein antibodies with neuropsychiatric systemic lupus erythematosus

  • A Ambrozic1,

    Affiliated with

    • B Bozic1,

      Affiliated with

      • B Rozman1,

        Affiliated with

        • B Lestan1 and

          Affiliated with

          • T Kveder1

            Affiliated with

            Arthritis Res Ther20046(Suppl 1):6

            DOI: 10.1186/ar1048

            Received: 16 January 2004

            Published: 24 February 2004


            There is an unclear association of anti-P with neuropsychiatric (NP) SLE.


            Our objective was to determine the prevalence of anti-P in 150 SLE patients, focusing on psychosis and/or mood disorders, other diffuse NP syndromes and focal NP syndromes, and to analyze the manifestation of NP syndromes regarding SLE duration and anti-P status.


            One hundred and fifty Caucasian SLE patients (133 female, 17 male) were studied, 88 of whom had a disease duration of more than 5 years. IgG anti-P were detected by immunoblotting performed on ribosomal extract of HeLa cells and/or by line immunoassay (INNO LIA ANA). NP manifestations presenting at any time were defined according to ACR case definitions for NP SLE. Patients in whom diffuse and focal NP manifestations occurred at the same time were classified according to the predominant manifestation.


            Anti-P were positive in 17/150 (11.3%) patients. Diffuse NP manifestations were diagnosed in 9/17 (53%) anti-P positive patients (Table 1). Statistically significant associations of anti-P were found with (1) psychosis and/or mood disorders (3/11, P < 0.05), (2) other diffuse NP syndromes (6/14, P < 0.0001), and (3) all diffuse NP syndromes (9/25; P < 0.0001), as compared with patients without diffuse NP manifestations (7/92). In the group of 88 patients with disease duration greater than 5 years, an even stronger statistically significant association of anti-P with diffuse NP manifestations was found.
            Table 1

            Study findings


            Anti-P positive (n = 17)

            Anti-P negative (n = 133)


            Psychosis and/or mood disorders

            3 (18%)

            8 (6%)


            Other diffuse NP syndromes

            6 (35%)

            8 (6%)


            Only focal NP syndromes

            1 (6%)

            32 (24%)


            Without NP manifestations

            1 (41%)

            85 (64%)


            In our study anti-P antibodies showed a strong association with diffuse but not focal NP syndromes in SLE patients, especially those with disease duration over 5 years.

            Authors’ Affiliations

            Department of Rheumatology, University Medical Centre


            © BioMed Central Ltd 2004