Volume 3 Supplement 2

21st European Workshop for Rheumatology Research

Open Access

Elevated levels of soluble intercellular adhesion molecule -1 in systemic lupus erythematosus

  • N Kljukvina1,
  • S Shekshina1,
  • E Alexandrova1,
  • A Novicov1 and
  • E Nassonov1
Arthritis Research & Therapy20013(Suppl 2):P034

DOI: 10.1186/ar203

Received: 15 January 2001

Published: 26 January 2001

Objective

To assess the value of measuring serum levels of soluble intercellular adhesion molecule 1 (sICAM-1) in systemic lupus erythematosus (SLE).

Material and methods

We studied 35 patients (pts) (7 female, 28 male), satisfying the ACR criteria for SLE. Mean age of pts was 31,4 ± 12,0 years (range 17-63), mean disease duration was 81,8 ± 70,5 month (range 2-240). Disease activity was assessed by disease activity indices (SLAM, SLEDAI). Enzyme-linked immunosorbent assay was used to measure levels of sICAM-1 (R$D, USA). The results were compared with 18 healthy subjects.

Results

Levels of sICAM-1 were found elevated (more than 2 SD above the mean in normal controls, 443 ng/ml) in 7 of 35 (20%) pts with SLE. The relations between positive sICAM-1 and some clinical manifestations of SLE have been detected. We found significant correlation between individual sICAM-1 serum level and the SLEDAI (r=043) and SLAM (r=0,56) scores, and ESR (r=0,53).

Conclusion

Elevated serum levels of sICAM-1 can be found in SLE and correlate with disease activity. Longitudinal studies may establish their clinical value in the monitoring or the prognosis of patients.

Table 1

Parameters,

Positive sICAM-1

Negative sICAM-1

 

(%) or mean ± SD

(n = 7)

(n = 28)

P

ICAM-1, ng/ml

512,3 ± 45,5

284,3 ± 85,0

<0,001

Malar rash

28,6%

14,2%

NS

arthritis

42,8%

25%

NS

nephritis

57,2%

32,1%

NS

CNS involvement

71,4%

39,3%

NS

Serositis

42,8%

14,3%

NS

ESR, mm/h

38,0 ± 24,8

21,2 ± 16,1

<0,05

SLAM, score

16,0 ± 7,4

9,03 ± 5,7

<0,05

SLEDAI, score

18,0 ± 12,4

10,2 ± 7,75

<0,05

Authors’ Affiliations

(1)
Moscow Medical Academy, Institute of Rheumatology of RAMS

Copyright

© BioMed Central Ltd 2001

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