Correction: Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity?

  • Stephen Eyre1Email author,

    Affiliated with

    • John Bowes1,

      Affiliated with

      • Catherine Potter1,

        Affiliated with

        • Jane Worthington1 and

          Affiliated with

          • Anne Barton1

            Affiliated with

            Arthritis Research & Therapy200810:405

            DOI: 10.1186/ar2469

            Published: 8 August 2008

             

            Following publication of our article [1] we have noticed the following error in nomenclature: All four polymorphisms studied were referred to as FCRL3-169*C/T.

            FCRL3-169*C/T (fclr3_3, rs7528684) is correctly named.

            FCRL3-169*C/T (fclr3_4, rs11264799) should be FCRL3-110*C/T (fclr3_4, rs11264799).

            FCRL3-169*C/T (fclr3_5, rs945635) should be FCRL3+358*C/G (fclr3_5, rs945635).

            FCRL3-169*C/T (fclr3_6, rs3761959) should be FCRL3+1370*A/G (fclr3_6, rs3761959).

            Thus, Table 1 should appear as shown.
            Table 1

            Genotype frequencies of Fc receptor-like 3 (FCRL3) single nucleotide polymorphisms in rheumatoid arthritis cases, in controls and in subgroups

            Single nucleotide polymorphism

            Controls

            Cases

            Two-copy shared epitope allelesb

            Rheumatoid factor-positive a,c

               

            Controls

            Cases

             

            FCRL3-169*C/T (fclr3_3, rs7528684)

               T/T

            595 (28.7)

            324 (30.4)

            45 (36.9)

            71 (32.0)

            324 (30.4)

               C/T

            1055 (50.9)

            524 (49.2)

            52 (42.6)

            103 (46.4)

            524 (49.2)

               C/C

            423 (20.4)

            217 (20.4)

            25 (20.5)

            48 (21.6)

            217 (20.4)

               P value

            0.57

             

            0.69

             

            0.57

            FCRL3-110*C/T (fclr3_4, rs11264799)

               1/1

            258 (53.3)

            404 (53.1)

            13 (50.0)

            132 (52.6)

            404 (53.1)

               1/2

            190 (39.3)

            296 (38.9)

            10 (38.5)

            95 (37.8)

            296 (38.9)

               2/2

            36 (7.4)

            61 (8.0)

            3 (11.5)

            24 (9.6)

            61 (8.0)

               P value

            0.93

             

            0.94

             

            0.93

            FCRL3+358*C/G (fclr3_5, rs945635)

               1/1

            123 (27.9)

            209 (28.4)

            9 (36.0)

            64 (27.3)

            209 (28.4)

               1/2

            200 (45.3)

            362 (49.3)

            12 (48.0)

            116 (49.6)

            362 (49.3)

               2/2

            118 (26.8)

            164 (22.3)

            4 (16.0)

            54 (23.1)

            164 (22.3)

               P value

            0.46

             

            0.57

             

            0.46

            FCRL3+1370*A/G (fclr3_6, rs3761959)

               1/1

            124 (26.3)

            209 (27.8)

            8 (30.8)

            65 (27.1)

            209 (27.8)

               1/2

            220 (46.7)

            370 (49.3)

            12 (46.1)

            120 (50.0)

            370 (49.3)

               2/2

            127 (27.0)

            172 (22.9)

            6 (23.1)

            55 (22.9)

            172 (22.9)

               P value

            0.28

             

            0.91

             

            0.28

            Data presented as n (%). aComparison group = all controls. bSubgroup stratified by two copies of shared epitope alleles. cSubgroup stratified by the presence of rheumatoid factor (measured cumulatively).

            Within 'Patients and methods', the paragraph 'Polymorphisms selected' should read as follows:

            Four SNPs – FCRL3-169*C/T (fclr3_3, rs7528684), FCRL3-110*C/T (fclr3_4, rs11264799), FCRL3+358*C/G (fclr3_5, rs945635) and FCRL3+1370*A/G (fclr3_6, rs3761959) – were initially selected for investigation because they had all been associated with RA in the Japanese population on single-point analysis, because the SNPs formed a haplotype associated with RA and because the most probable disease causal SNP (FCRL3-169*C/T (fclr3_3, rs7528684)) was included [7].

            The second paragraph of 'Results' should read as follows:

            No deviation from Hardy–Weinberg expectations was observed for any of the SNPs in either cases or controls. Interim analysis after genotyping a subset of the total cohort revealed that extensive linkage disequilibrium was present across the four SNPs tested. Indeed, the D' value between all the SNPs was 0.98 while the correlation between SNPs FCRL3-169*C/T (fclr3_3, rs7528684), FCRL3+358*C/G fclr3_5 (rs945635) and FCRL3+1370*A/G fclr3_6 (rs3761959) was also 0.98 in this sample. The correlation between these SNPs and FCRL3-110*C/T fclr3_4 (rs11264799) was 0.6 or greater, reflecting the difference in allele frequency of this SNP compared with the others. Hence, genotyping of all four SNPs was unnecessary and, in the remaining samples, only the putative disease causal polymorphism was genotyped.

            The above changes in no way affect the conclusions of the study.

            Declarations

            Authors’ Affiliations

            (1)
            ARC-EU, University of Manchester

            References

            1. Eyre S, Bowes J, Potter C, Worthington J, Barton A: Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity? Arthritis Research & Therapy 2006, 8:R117.View Article

            Copyright

            © BioMed Central Ltd 2008

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