Volume 3 Supplement 2

21st European Workshop for Rheumatology Research

Open Access

Positivity of HLA-DRB1 rheumatoid epitope does not predict the course of juvenile idiopathic arthritis in Czech children

  • O Cinek1,
  • P Vavrincová1,
  • P Drevínek1,
  • M Suková1,
  • S Rádová2 and
  • J Vavrinec1
Arthritis Research & Therapy20013(Suppl 2):P104

DOI: 10.1186/ar273

Received: 15 January 2001

Published: 26 January 2001

Aims

Association of juvenile idiopathic arthritis (JIA) with HLA class II still remains unresolved. Our study investigated whether presence of the HLA-DRB1 amino acid 70-74 rheumatoid epitope (RE) is a predictive factor of the disease course.

Patients and methods

We analysed 74 consecutive patients with JIA diagnosed and classified according to ILAR criteria, aged 11.2 ± 4.2 (mean ± SD), 35 boys and 39 girls. The numbers of children having oligoarticular, polyarticular, and systemic form of JIA were 24, 40, and 10, respectively. HLA-DRB1 alleles carrying the QRRAA, QKRAA, and RRRAA motifs of RE were typed for using PCR with sequence-specific primers.

Results and Conclusions

There were no significant differences in frequency of the RE, or its particular motifs, among the three forms of JIA.

We therefore conclude that simple positivity of the DRB1 rheumatoid epitope is not a likely predictive factor of the JIA course in Czech children.
 

JIA

JIA

JIA

  
 

oligo.

poly.

systemic

Total

P value

RE negative

16

25

6

47

N.S.

RE positive

8

15

4

27

N.S.

Total

24

40

10

74

 

The 2×2 table were tested using chi2 test with Yate's correction, or Fisher exact test where appropriate.

Authors’ Affiliations

(1)
2nd Paediatric Department, 2nd Medical Faculty
(2)
University Hospital Motol

Copyright

© BioMed Central Ltd 2001

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