Predicting joint damage in rheumatoid arthritis using MRI scanning
© BioMed Central Ltd 2009
Published: 14 September 2009
Predicting prognosis in the patient with newly diagnosed rheumatoid arthritis is of key importance so that high-cost therapies can be tailored to the needs of the individual. In a recent issue of Arthritis Research and Therapy, the prognostic significance of MRI changes at the forefoot has been studied. While progression to radiographic erosion occurred rarely in this group of patients exposed to potent disease-suppressing therapies, including TNF inhibitors, MRI bone edema, representing osteitis, has been further implicated as a forerunner to bone erosion. Early MRI scans of the forefoot were helpful in defining those with the potential to progress as well as those in a good prognosis category.
In a recent issue of Arthritis Research and Therapy, Mundwiler and colleagues  have investigated the prognostic significance of magnetic resonance imaging (MRI) changes at the forefoot in patients with early rheumatoid arthritis (RA). While there is already an extensive literature investigating the hand and wrist in this context [2–4], much less information exists regarding the forefoot, where radiographic (XR) changes appear early . A previous study has indicated that MRI synovitis, bone edema and erosion can be detected within weeks of the onset of symptoms , and of these features, bone edema has repeatedly been shown to be the most important predictor of future erosions at the wrist [2–4]. It is therefore timely to examine the importance of MRI scanning of the feet, using a longitudinal study design to define early prognostic markers.
Mundwiler and colleagues set out primarily to determine the sensitivity, specificity, and predictive value of MRI erosions at individual metatarsophalangeal (MTP) joints for the development of new XR erosions after 6, 12, and 24 months. Secondary objectives were to determine the prognostic significance of MRI synovitis and bone edema and to examine the persistence of those findings over time. Their cohort of patients differed from those studied by McQueen and colleagues  in that almost half (46%) had received anti-TNF therapy and were, therefore, representative of a modern RA population receiving aggressive management in the biologics era. Comparing their results with those of previous similar studies is a most interesting exercise. At first glance they might seem to be contradictory as the presence of an MRI erosion at baseline had a low positive predictive value for the later development of an XR erosion at that site (0.17 at 24 months). However, the negative predictive value was extremely high at 0.99, virtually guaranteeing that, in its absence, an XR erosion would not develop. This is a very similar result to that described previously in the New Zealand cohort where the negative predictive value for MRI erosions predicting XR erosions after 1 year was 0.91 . The reason why the positive predictive values were so low in the Mundwiler cohort was that this group hardly eroded at all. Only five new XR erosions actually formed for the entire group over the 24-month period, presumably reflecting the impact of modern disease-suppressing therapies, including anti-TNF agents.
What do the findings of Mundwiler and colleagues tell us about the role of synovitis as a pre-erosive lesion? Synovitis was common, being observed in 74% of cases. It was detected as an isolated finding in 52 MTP joints and in these it resolved in two-thirds of cases without the appearance of other lesions. In one-quarter of cases, synovitis persisted without other lesions appearing, and in only 6% of MTPs, where it was an initial isolated finding, did bony lesions develop. This would tend to imply that while synovitis is a very common finding in RA, it is not in itself pre-erosive. Its strong association with bone edema (which was accompanied here by synovitis in all but one instance) suggests that the lesions are often linked but this is not invariable. In those patients with pure synovitis and without bone edema, the prognosis may be more favourable. Further studies to follow the progress of these 'good prognosis' patients are warranted as the 'hit hard and early' treatment philosophy may not serve in their best interests. Conversely, the appearance of definite bone edema needs to serve as a red flag for rheumatologists and active management with powerful anti-erosive medications such as TNF inhibitors should be considered urgently for these patients.
magnetic resonance imaging
tumor necrosis factor
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