Volume 14 Supplement 1
Increased concentration of serum soluble LAG3 in systemic lupus erythematosus
© Yu et al.; licensee BioMed Central Ltd. 2012
Published: 29 February 2012
In systemic lupus erythematosus (SLE), type I interferon and plasmacytoid DCs (pDCs) are supposed to play important roles. However, there are few evidences for pDCs activation in SLE. Murine pDCs are reported to produce soluble LAG3 (sLAG3) upon activation and pDCs are responsible for most of sLAG3 in mice serum . Therefore, serum sLAG3 concentration was examined in SLE and other autoimmune diseases.
Materials and methods
This study enrolled 45 SLE patients who met ACR criteiria. Disease activity was rated using a SLE disease activity index (SLEDAI). sLAG3 concentrations were measured by a quantitative sandwich enzyme immunoassay .
The ratio of sLAG3 concentration in SLE to control was 3.10+/-1.05, PM/DM to control was 1.04+/-0.08, and RA to control was 0.77+/-0.14. In addition, sLAG3 concentrations showed a significant correlation with SLEDAI. Interestingly, elevation of sLAG3 was observed even in patients with SLEDAI = 0. These results suggested that sLAG3 could be a specific and novel marker for SLE.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.