Volume 14 Supplement 1
Unc93 homolog B1 restricts systemic lethal inflammation by orchestrating TLR7 and TLR9 response
© Fukui et al.; licensee BioMed Central Ltd. 2012
Published: 29 February 2012
Nucleotide sensing-TLRs (Toll-like receptors) recognize pathogen derived-nucleic acids and trigger immune response . Because of the highly conserved structure of nucleic acids, these TLRs have risk to recognize host derived-nucleic acids and induce autoimmune disease, therefore it is important to clarify the mechanisms and control the response.
It is reported that TLR7 or TLR9 response contributes to some kinds of autoimmune disease and TLR7 overexpressed mice develop SLE like autoimmune disease [4–8]. To investigate the significance of reciprocal TLR7/TLR9 balance in vivo, we generated Unc93b1D34A/D34A mice and observed the phenotypes.
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.