Volume 14 Supplement 2

Proceedings of Osteorheumatology 2011: International Congress on Bone Involvement in Arthritis

Open Access

IL-1 inhibition in autoinflammatory diseases

  • Alberto Martini1
Arthritis Research & Therapy201214(Suppl 2):A4

DOI: 10.1186/ar3711

Published: 8 March 2012

Inherited autoinflammatory syndromes (IAS) are a group of recently identified monogenic diseases characterized by recurrent episodes of systemic inflammation.

Muckle-Wells Syndrome, Familial Cold Autoinflammatory Syndrome and Chronic Infantile Neurological Cutaneous and Articular Syndrome are IAS due to mutations in a single gene, CIAS1 (cold-induced autoinflammatory syndrome 1, or NALP-3), encoding a protein called cryopyrin which is an essential component of an intracellular multiprotein complex named inflammasome, that play a crucial role in the production and secretion of interleukin (IL)-1 These diseases are characterized by excessive production of IL-1 and have a dramatic response to IL-1 inhibition.

More recently, IL-1 inhibition has also been shown to be effective in another AID (TNF-receptor associated periodic syndrome or TRAPS) as well as in other conditions such as systemic juvenile idiopathic arthritis and recurrent idiopathic pericarditis. This has suggested that also these two last diseases may represent autoinflammatory conditions.

Authors’ Affiliations

Department of Pediatrics, University of Genoa, Pediatria II Reumatologia, Istituto G Gaslini


© Martini; licensee BioMed Central Ltd. 2012

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.