Rituximab in patients with rheumatoid arthritis in routine practice (GERINIS): six-year results from a prospective, multicentre, non-interventional study in 2,484 patients
© Wendler et al.; licensee BioMed Central Ltd. 2014
Received: 16 August 2013
Accepted: 11 March 2014
Published: 26 March 2014
The aim of this study was to evaluate the safety and efficacy of rituximab (RTX) in a large cohort of patients with rheumatoid arthritis in routine care, and to monitor changes in daily practice since the introduction of RTX therapy.
This was a multicentre, prospective, non-interventional study conducted under routine practice conditions in Germany. Efficacy was evaluated using Disease Activity Score in 28 joints (DAS28) and Health Assessment Questionnaire-Disability Index (HAQ-DI). Safety was assessed by recording adverse drug reactions (ADRs). Physician and patient global efficacy and tolerability assessments were also evaluated.
Overall, 2,484 patients (76.7% female, mean age 56.4 years, mean disease duration 11.7 years) received RTX treatment (22.7% monotherapy). The total observation period was approximately six-years (median follow-up 14.7 months). RTX treatment led to improvements in DAS28 and HAQ-DI that were sustained over multiple courses. DAS28 improvements positively correlated with higher rheumatoid factor levels up to 50 IU/ml. Response and tolerability were rated good/very good by the majority of physicians and patients. Mean treatment intervals were 10.5 and 6.8 months for the first and last 400 enrolled patients, respectively. Infections were the most frequently reported ADRs (9.1%; 11.39/100 patient-years); approximately 1% of patients per course discontinued therapy due to ADRs.
Prolonged RTX treatment in routine care is associated with good efficacy and tolerability, as measured by conventional parameters and by physicians’ and patients’ global assessments. Rheumatoid factor status served as a distinct and quantitative biomarker of RTX responsiveness. With growing experience, physicians repeated treatments earlier in patients with less severe disease activity.
The anti-CD20 monoclonal antibody rituximab (RTX) was licensed in 2006 in combination with methotrexate (MTX) for the treatment of severe, active rheumatoid arthritis (RA) in adult patients with an inadequate response to disease-modifying antirheumatic drugs (DMARDs) including one or more tumour necrosis factor (TNF) inhibitors. Based on the pioneering idea that RTX might be of value in the treatment of seropositive RA, a proof of concept study confirmed its efficacy and safety in combination with MTX and thereby provided strong evidence for the role of B cells in this disease . RTX is distinct from other biological DMARDs, with regards to its mode of action which involves the targeting of CD20+ B cells resulting in the inhibition of B-cell-mediated inflammatory responses. Another unique feature of RTX is the long interval between treatment courses; the selective depletion of CD20-positive B cells by RTX results in a long duration of therapeutic response with each course of treatment . RTX retreatment is generally recommended at around six months based on clinical evaluation , whereas other RA biologicals are administered using monthly or more frequent regimens. The less frequent dosing schedule of RTX means that more prolonged follow-up may be needed in order to properly evaluate physicians’ and patients’ experiences with this therapy.
Extensive data on the long-term efficacy and safety profile of RTX are now available, mainly from long-term follow-up of patients participating in the RTX clinical trial programme. Five-year efficacy data from the REFLEX trial extension have recently been reported , as have been safety data from a pooled analysis of all RTX clinical trials with a follow-up of 10 years, involving up to 17 courses . However, clinical trials are biased by the requirements of patient exclusion and inclusion criteria, and it is estimated that only about 30% of daily practice patients would be eligible for such studies . Consequently, data obtained in real-life settings are also valuable. Such data from RTX-treated patients have been reported from a number of European registries, although generally involving relatively shorter periods of follow-up [7–11].
This very large, non-interventional study was initiated in Germany in 2006 when RTX was first authorised for RA treatment. The main purpose of the study was to evaluate the safety and efficacy of RTX in routine RA care. An additional objective was to monitor changes in daily practice during the period following the introduction of RTX, for example, with regard to retreatment or concomitant therapy, and whether specific variables, such as patient age, influence treatment outcomes.
Materials and methods
This was a multicentre, prospective, non-interventional study, the primary objective of which was to assess the long-term efficacy and safety of RTX in patients with active RA in a routine practice setting. Participating physicians were rheumatologists practising at 215 outpatient clinics or private practices in Germany. A list of study investigators and sites is provided in Additional file 1. Patients received RTX treatment and retreatment according to the discretion of the physician. Patient data were collected for a period of two years after the start of the first RTX treatment course. If patients required retreatment, the two-year observation period was restarted at the point of RTX retreatment. Clinical visits were documented at baseline (first infusion), Day 15 (second infusion) and, as available, at months 4, 8, 12, 16, 20 and 24.
In accordance with Section 67, Sub-Section 6 of the German Drug Law, the Federal Panel Doctors' Association, the Central Federal Association of health insurance funds and the competent higher federal authority were notified regarding the conduct of this non-interventional study. Ethical approval of the study and patient written consent were not obtained as neither was mandatory in Germany for non-interventional studies when the study commenced in 2006. The study was conducted in accordance with the principles of the Declaration of Helsinki.
The main parameter for evaluating efficacy was the Disease Activity Score in 28 joints (DAS28). Assessment of functional disability was performed using the Health Assessment Questionnaire-Disability Index (HAQ-DI). Safety was assessed by the occurrence of adverse drug reactions (ADRs) and infusion reactions (IRs). Measurement of rheumatoid factor (RF) was performed at the individual study sites, using nephelometry which primarily detects IgM RF. All clinical assessments were made by fully trained qualified health care professionals, although we accept that some degree of variation in both the competence and techniques applied across >200 outpatient clinics and private practices is likely to have occurred and may have influenced the results to some extent. Additionally, physicians and patients were asked to assess the global efficacy and tolerability of RTX therapy using the following four categories: very good, good, moderate and poor.
The safety population comprised all patients who had received at least one RTX infusion. The efficacy population comprised all patients with a primary diagnosis of RA and in whom at least one post-baseline efficacy measurement had been documented. All efficacy and safety parameters were analysed descriptively using SAS version 8.2 software (SAS Institute, Cary, North Carolina, USA). For numerical data, mean, standard deviation, median, range and interquartile ranges were calculated. Categorical data were analysed by calculating absolute and relative frequencies. Missing values were not imputed. Changes from baseline in efficacy parameters were used as outcome variables. Subgroup analyses were performed based on the following parameters: time of inclusion (first 400 enrolled patients versus last 400 enrolled patients), RF level, age and sex. Due to decreasing patient numbers with each treatment course, the efficacy evaluations in this analysis focused on the first three treatment courses. Correlation between baseline RF level and change in DAS28 was analysed using the Locally Estimated Scatterplot Smoothing (LOESS) non-parametric regression method . In brief, this involves the selection of a specific span (bandwidth) of points along the x-axis adjacent to the point being predicted. A regression equation is then fitted for the selected points through this subset of data giving more weight to points closest to the value being predicted. The resulting equation is then used to predict the value for the selected point. The data are then shifted one point to the right and the process is repeated. The resulting predicted values and confidence limits are connected together with lines. The smaller the bandwidth, the less smooth the final line. To improve the comparability of the data, the LOESS analysis included the subgroup of seropositive and seronegative patients with RF levels determined using the most frequently used diagnostic tests (normal ranges of <14, 15 or 20 IU/ml).
Demographics and baseline characteristics
Safety population (n = 2,484*)
Patients enrolled early (n = 400)
Patients enrolled late (n = 400)
Female, n (%)
Age (years), mean ± SD
56.4 ± 12.4 (n = 2,474)
55.1 ± 12.1
56.9 ± 12.4
Duration of disease before study, years, mean ± SD
11.7 ± 9.6 (n = 2,168)
12.3 ± 9.3
11.9 ± 9.9
RF-positive, n (%)
1477 (77.3) (n = 1,910)
277 (78.5) (n = 353)
232 (77.6) (n = 299)
Treatment duration (months) over all study courses, mean ± SD
17.2 ± 13.7 (n = 2,484)
22.4 ± 17.0
9.1 ± 7.9
No. of previous DMARD baseline treatments including TNF antagonists, median
No. of previous conventional DMARD baseline treatments, median
No. of baseline TNF antagonists, median†
Previous TNF antagonists, n (%)†
No. of different TNF antagonists per patient, mean ± SD
1.4 ± 1.0
Most frequent previous
DMARD baseline treatments, n (%)
Baseline DAS28, mean ± SD‡
5.7 ± 1.2 (n = 1,954)
5.9 ± 1.2 (n = 384)
5.4 ± 1.3 (n = 349)
Baseline HAQ, mean ± SD‡
1.6 ± 0.7 (n = 2,078)
1.74 ± 0.70 (n = 389)
1.56 ± 0.73 (n = 384)
Time between first and second course (months), mean ± SD‡
9.6 ± 4.4 (n = 1,306)
10.5 ± 4.9 (n = 250)
6.8 ± 1.6 (n = 143)
In the efficacy subgroup, baseline DAS28 scores at courses 1, 2 and 3 were 5.7, 5.0 and 4.6, respectively. Mean change from baseline in DAS28 during the first treatment course was -1.4 points at month 4 and -1.4 points at month 8. After three treatment courses, mean DAS28 decreased to 3.6 at both the four-month and eight-month time points. In parallel with the improvements in DAS28 score, an increasing proportion of patients achieved low disease activity (LDA) status with each additional treatment course. The proportion of patients with LDA increased from 3.5% at baseline prior to course 1 to 23.7% (course 1, month 8), 30.8% (course 2, month 8) and 42.4% (course 3, month 8). Patients with exposure to more than one previous TNF inhibitor also benefitted from RTX retreatment: the proportion of patients with DAS28 remission increased from 9.8% (course 1, month 8) to 29.5% (course 3, month 8).
Physician-reported mean swollen joint count (28 joints) decreased from 7.9 at baseline to 4.1 at month 4, and to 4.1 at month 8 of course 1, with further decreases observed during each subsequent course. In parallel, tender joint count (28 joints) decreased from 11.0 at baseline to 6.1 at month 8 of course 1, and to 4.3 at month 8 of course 3.
During the first treatment course, mean HAQ-DI values showed clinically meaningful improvements (a decrease of >0.22 points) of 0.22 points between baseline and month 4 and of 0.24 points between baseline and month 8. High proportions of patients showed a clinically meaningful decrease of HAQ-DI at month 8 following each RTX course even though the baseline values were lower: course 1, 48.6%; course 2, 42.0%; course 3, 32.6%.
Overview of safety and efficacy of RTX treatment stratified by age
Age group (years)
40 to <60
Safety, n (%)
No. of patients
Efficacy, DAS28 (mean [SD])
No. of patients (baseline)
No. of patients (baseline)
The first 400 patients entered the study between July 2006 and February 2007, while the last 400 patients were enrolled between January and October 2009. The interval between these two periods was shorter than initially planned due to faster than expected enrolment. In general, physicians tended to include patients with less severe disease later in the study; baseline DAS28 was higher in the early group compared with the later group (mean 5.9 versus 5.4). In addition, patients in the early group had received a greater median number of DMARDs at baseline (5.1 versus 3.8) and were on average slightly younger than those in the later group (55.1 versus 56.9 years). The mean time to retreatment was considerably longer in the early group compared with the later group (10.5 versus 6.8 months) (Table 1).
Global assessment of efficacy and tolerability
ADRs were reported in 532 patients (21.4%; 39.58/100 patient-years) overall (Table 2). The most frequent ADRs were infections and parasitic diseases (9.1%; 11.39/100 patient-years), with the most frequent infection being nasopharyngitis (1.8%; 1.61/100 patient-years). Skin and subcutaneous tissue disorders were also common (5.5%; 5.48/100 patient-years), and mainly pruritus (1.5%; 1.39/100 patient-years). All other reported ADRs occurred at a frequency of <5% (<5/100 patient-years). Serious ADRs were reported by 76 patients (3.1%; 4.44/100 patient-years). Overall, IRs were reported in 157 patients (6.3%; 3.62/100 patient-years). The incidence of IRs was highest during course 1 (4.3% (95/2,195)) and then declined with subsequent courses (3.0% (46/1,509)) for course 2 and 1.8% [16/909] for course 3. RTX infusions were interrupted due to ADRs in 30 patients. Nine patients (0.4%; 0.40/100 patient-years) had serious IRs.
Cases of sepsis were rare: general sepsis (n = 3), septic shock (n = 2), and urosepsis (n = 1). Single cases of the following fungal infections were reported (as described in the safety report): fungal infection, sinusitis due to fungal infestation, tinea corporis, tinea pedis, dermal fungal infection, gastointestinal candidosis, oral candidosis, vaginal candidosis and vulvovaginal fungal infection. No cases of hepatitis or atypical mycobacterial infection were reported. One patient died who had tuberculosis and sepsis. No cases of progressive multifocal leukoencephalopathy were reported throughout the observation period.
The proportions of patients reporting ADRs and serious ADRs were also similar in the three age groups. There were no apparent differences between RF-positive and RF-negative patients in the frequency of overall ADRs (23.1 versus 21.1%, respectively) or serious infections and parasitic diseases (1.2 versus 0.9%, respectively).
Nine patients died during the study. Six of these deaths were considered not related to RTX. In one case causality was assessed as not applicable and two cases were assessed as possibly related (one patient died due to postoperative complications including sepsis and the other due to an acute respiratory distress syndrome).
Non-interventional studies can provide valuable data with regard to the efficacy and safety of therapies in a real-life setting. This study, conducted in routine clinical practice in Germany over a period of approximately six years starting soon after the marketing authorisation of RTX, is possibly the largest of its type with the inclusion of over 2,400 patients. The results indicate that RTX treatment was associated with favourable efficacy outcomes over multiple courses, with significant decreases in DAS28 accompanied by clinically meaningful changes in HAQ-DI. The findings are in line with those previously reported from RTX clinical trials [4, 13] and European registries [7, 8, 10]. In addition, the results provide convincing documentation of changes in clinical practice over time and the first evidence indicating a quantitative relationship between RF level and response to RTX. A sub-analysis of our study further demonstrated the effectiveness of RTX in older patients, with outcomes observed in patients over 60 years of age comparable with those seen in younger patients. Interestingly, IRs were less frequent in patients of 60 years or older compared with patients younger than 60 years old. To our knowledge this is the first report of the influence of age on RTX efficacy and safety.
A longitudinal analysis of the data suggests that there have been some changes in physicians’ practices since RTX was first licensed for treatment of RA in 2006. By comparing data from the first 400 enrolled patients with those from the last 400 enrolled patients, a period separated by approximately 2.5 years, the results suggest that, over time, physicians changed to using RTX in patients with less severe disease. In addition, RTX retreatment intervals generally shortened over the time of the study. These observations of changes in daily practice likely reflect the introduction into clinical practice in Germany of guidelines recommending a treatment to target approach for RA biological therapies [3, 14, 15]. It is worth noting that a small minority (approximately 3.5%) of patients were treated with rituximab despite having LDA; the reasons for this non-standard approach are not clear as this information was not collected during the study. However, a number of explanations are possible, including individual consideration of patient treatment according to disease history; discontinuation of prior therapy due to intolerability while having LDA; or physician preference to target remission even when LDA had been achieved.
The summary of product characteristics recommends that RTX is administered in combination with MTX . It is interesting to note, therefore, that nearly one-quarter (23%) of patients in the current study received RTX as monotherapy. The reasons for this relatively high proportion are not clear. MTX may be contraindicated in some patients and not tolerated by others, although other reasons, such as physicians’ or patients’ preference, may also have been involved. The efficacy outcomes associated with RTX monotherapy were generally similar to those achieved with RTX in combination with MTX or LEF. Interestingly, the present analysis of the complete data set differs from a previous interim analysis of 995 patients, which indicated that RTX plus LEF provided superior outcomes (EULAR responses) to that of RTX plus MTX . Other previous studies have reported that RTX monotherapy is similar to RTX plus MTX in terms of short-term efficacy [18, 19], while another study reported that RTX plus LEF gave better outcomes than RTX alone or in combination with MTX . Data from a phase II trial indicated that the probability of achieving higher hurdle clinical endpoints, such as ACR50 or ACR70, is increased when RTX is administered in combination with MTX rather than as monotherapy .
Patients seropositive for RF have been shown previously to exhibit greater efficacy responses to RTX than those who are seronegative [7, 9, 11, 18, 21, 22]. In this non-interventional study, patients with higher RF levels tended to have greater DAS28 and HAQ responses than those with lower levels. These data further support the use of RF status as a biomarker for predicting RTX responsiveness and may extend this correlation to a quantitative relationship. The results of the LOESS analysis indicated that RTX responsiveness increases up to an RF level of approximately 50 IU/ml, with no further increases seen above this level. Although seronegative and low-level RF positive patients tended to respond less well to RTX, the results indicate that some of these patients, perhaps around 50%, may still benefit from RTX therapy.
The safety profile of RTX has been established primarily from long-term follow-up of patients in the RTX clinical trial programme [5, 23]. Real-life studies, such as the current non-interventional study, are invaluable as they include patients with significant comorbidities or other demographic and disease characteristics that would exclude them from formal clinical trials. RTX was rated as good or very good in terms of both efficacy and tolerability by the majority of physicians and patients in this study. As would be expected from a real-life study, the proportion of patients reporting ADRs was generally lower than that reported in the RTX clinical trials [5, 23].
The study has a number of possible limitations due to the non-interventional design with lack of a control group that limit a more reliable evaluation of efficacy and tolerability of RTX. Moreover, adverse event rates may be underestimated due to less stringent requirements when compared with randomised clinical trials. Finally, assessment of subgroups (for example, age) was somewhat limited by smaller patient numbers in these groups. Despite these limitations, the study provides insights into daily clinical practice beyond a rather selected patient group often enrolled in clinical studies.
In conclusion, the results of this large non-interventional study involving 2,484 patients with observation over six years indicate that RTX is efficacious and well tolerated in routine care in Germany, including in older patients, with improved efficacy results in RF-positive patients. In addition, the results demonstrate that RTX monotherapy and in combination with LEF may represent an alternative for some patients intolerant to MTX. This study also provides evidence that changes in the use of RTX to treat RA have occurred in recent years, thus indicating that physicians have adopted this therapy and have developed how it is used in routine care.
Adverse drug reaction
Disease activity score in 28 joints
Disease-modifying antirheumatic drugs
Health assessment questionnaire-disability Index
Low disease activity
Locally estimated scatterplot smoothing
Tumour necrosis factor.
Third party writing assistance for this manuscript was provided by Neil Anderson, PhD and funded by Roche Pharma AG, Grenzach-Wyhlen, Germany.
- Edwards JC, Szczepanski L, Szechinski J, Filipowicz-Sosnowska A, Emery P, Close DR, Stevens RM, Shaw T: Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med. 2004, 350: 2572-2581. 10.1056/NEJMoa032534.View ArticlePubMedGoogle Scholar
- Keystone E, Fleischmann R, Emery P, Furst DE, van Vollenhoven R, Bathon J, Dougados M, Baldassare A, Ferraccioli G, Chubick A, Udell J, Cravets MW, Agarwal S, Cooper S, Magrini F: Safety and efficacy of additional courses of rituximab in patients with active rheumatoid arthritis: an open-label extension analysis. Arthritis Rheum. 2007, 56: 3896-3908. 10.1002/art.23059.View ArticlePubMedGoogle Scholar
- Buch MH, Smolen JS, Betteridge N, Breedveld FC, Burmester G, Dörner T, Ferraccioli G, Gottenberg JE, Isaacs J, Kvien TK, Mariette X, Martin-Mola E, Pavelka K, Tak PP, van der Heijde D, van Vollenhoven RF, Emery P, Rituximab Consensus Expert Committee: Updated consensus statement on the use of rituximab in patients with rheumatoid arthritis. Ann Rheum Dis. 2011, 70: 909-920. 10.1136/ard.2010.144998.PubMed CentralView ArticlePubMedGoogle Scholar
- Keystone EC, Cohen SB, Emery P, Kremer JM, Dougados M, Loveless JE, Chung C, Wong P, Lehane PB, Tyrrell H: Multiple courses of rituximab produce sustained clinical and radiographic efficacy and safety in patients with rheumatoid arthritis and an inadequate response to 1 or more tumor necrosis factor inhibitors: 5-year data from the REFLEX study. J Rheumatol. 2012, 39: 2238-2246. 10.3899/jrheum.120573.View ArticlePubMedGoogle Scholar
- van Vollenhoven RF, Emery P, Bingham CO, Keystone EC, Fleischmann RM, Furst DE, Tyson N, Collinson N, Lehane PB: Long-term safety of rituximab in rheumatoid arthritis: 9.5-year follow-up of the global clinical trial programme with focus on adverse events of interest in RA patients. Ann Rheum Dis. 2013, 72: 1496-1502. 10.1136/annrheumdis-2012-201956.PubMed CentralView ArticlePubMedGoogle Scholar
- Zink A, Strangfeld A, Schneider M, Herzer P, Hierse F, Stoyanova-Scholz M, Wassenberg S, Kapelle A, Listing J: Effectiveness of tumor necrosis factor inhibitors in rheumatoid arthritis in an observational cohort study: comparison of patients according to their eligibility for major randomized clinical trials. Arthritis Rheum. 2006, 54: 3399-3407. 10.1002/art.22193.View ArticlePubMedGoogle Scholar
- Chatzidionysiou K, Lie E, Nasonov E, Lukina G, Hetland ML, Tarp U, Gabay C, van Riel PL, Nordström DC, Gomez-Reino J, Pavelka K, Tomsic M, Kvien TK, van Vollenhoven RF: Highest clinical effectiveness of rituximab in autoantibody-positive patients with rheumatoid arthritis and in those for whom no more than one previous TNF antagonist has failed: pooled data from 10 European registries. Ann Rheum Dis. 2011, 70: 1575-1580. 10.1136/ard.2010.148759.View ArticlePubMedGoogle Scholar
- Gottenberg JE, Ravaud P, Bardin T, Cacoub P, Cantagrel A, Combe B, Dougados M, Flipo RM, Godeau B, Guillevin L, Le Lot X, Haculla E, Schaeverbeke T, Sibilia J, Pane I, Abbe A, Baron G, Mariette X, French Society of Rheumatology: Prospective follow-up of RA patients (3680 patient/year) treated with rituximab in real life: results from the AIR registry [abstract]. Ann Rheum Dis. 2011, 70: 465-Google Scholar
- Strangfeld A, Eveslage M, Kekow J, Grabetaler A, Kaufmann J, Listing J, Zink A: Effectiveness of treatment with rituximab depends on autoantibody status - results from 2 years of experience in the German biologics register RABBIT [abstract]. Arthritis Rheum. 2009, 60: S634-S635.Google Scholar
- Vander Cruyssen B, Durez P, Westhovens R, Kaiser MJ, Hoffman I, De Keyser F, MIRA Study Group: The Belgian MIRA (MabThera In Rheumatoid Arthritis) registry: clues for the optimization of rituximab treatment strategies. Arthritis Res Ther. 2010, 12: R169-10.1186/ar3129.PubMed CentralView ArticlePubMedGoogle Scholar
- Van Vollenhoven RF, Chatzidionysiou K, Nasonov E, Lukina G, Hetland ML, Tarp U, Gabay C, Van Riel PL, Nordstrom DC, Gomez-Reino JJ, Pavelka K, Tomsic M, Lie E, Kvien TK: Six-month results from the collaborative European registries for rituximab in rheumatoid arthritis (CERERRA). Efficacy of rituximab is highest in RF-positive patients and in those who failed at most one prior anti-TNF [abstract]. The 2009 ACR/ARHP Annual Scientific MeetingPhiladelphia, October 16-21, 2009. Arthritis Rheum. 2009, 60 (suppl): S624-S625.Google Scholar
- Cleveland WS: Robust locally weighted regression and smoothing scatterplots. J Am Stat Assoc. 1979, 74: 829-836. 10.1080/01621459.1979.10481038.View ArticleGoogle Scholar
- Keystone EC, Fleischmann RM, Emery P, Dougados M, Williams S, Linnik MD, Reynard M: Multiple courses of rituximab produce sustained efficacy in patients with rheumatoid arthritis with an inadequate response to one or more TNF Inhibitors [abstract]. Arthritis Rheum. 2010, 62 (suppl): S133-Google Scholar
- Smolen JS, Aletaha D, Bijlsma JW, Breedveld FC, Boumpas D, Burmester G, Combe B, Cutolo M, de Wit M, Dougados M, Emery P, Gibofsky A, Gomez-Reino JJ, Haraoui B, Kalden J, Keystone EC, Kvien TK, McInnes I, Martin-Mola E, Montecucco C, Schoels M, van der Heijde D, T2T Expert Committee: Treating rheumatoid arthritis to target: recommendations of an international task force. Ann Rheum Dis. 2010, 69: 631-637. 10.1136/ard.2009.123919.PubMed CentralView ArticlePubMedGoogle Scholar
- Smolen JS, Landewé R, Breedveld FC, Dougados M, Emery P, Gaujoux-Viala C, Gorter S, Knevel R, Nam J, Schoels M, Aletaha D, Buch M, Gossec L, Huizinga T, Bijlsma JW, Burmester G, Combe B, Cutolo M, Gabay C, Gomez-Reino J, Kouloumas M, Kvien TK, Martin-Mola E, McInnes I, Pavelka K, van Riel P, Scholte M, Scott DL, Sokka T, Valesini G: EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs. Ann Rheum Dis. 2010, 69: 964-975. 10.1136/ard.2009.126532.PubMed CentralView ArticlePubMedGoogle Scholar
- MabThera®: Summary of product characteristics.http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/000165/human_med_000897.jsp&mid=WC0b01ac058001d124,
- Wendler J, Sørensen H, Tony H, Richter C, Krause A, Rubbert-Roth A, Bogdan M, Burmester G: Effectiveness and safety of rituximab (RTX) monotherapy compared to RTX combination therapy with methotrexate or leflunomide in the German RTX-treatment of active rheumatoid arthritis in daily practice trial [abstract]. Ann Rheum Dis. 2009, 68: 76-Google Scholar
- Solau-Gervais E, Prudhomme C, Philippe P, Duhamel A, Dupont-Créteur C, Legrand JL, Houvenagel E, Flipo RM: Efficacy of rituximab in the treatment of rheumatoid arthritis. Influence of serologic status, coprescription of methotrexate and prior TNF-alpha inhibitors exposure. Joint Bone Spine. 2012, 79: 281-284. 10.1016/j.jbspin.2011.05.002.View ArticlePubMedGoogle Scholar
- Owczarczyk K, Hellmann M, Fliedner G, Röhrs T, Maizus K, Passon D, Hallek M, Rubbert A: Clinical outcome and B cell depletion in patients with rheumatoid arthritis receiving rituximab monotherapy in comparison with patients receiving concomitant methotrexate. Ann Rheum Dis. 2008, 67: 1648-1650. 10.1136/ard.2007.087023.View ArticlePubMedGoogle Scholar
- Chatzidionysiou K, Lie E, Nasonov E, Lukina G, Hetland ML, Tarp U, van Riel PL, Nordström DC, Gomez-Reino J, Pavelka K, Tomsic M, Kvien TK, van Vollenhoven RF, Gabay C: Effectiveness of disease-modifying antirheumatic drug co-therapy with methotrexate and leflunomide in rituximab-treated rheumatoid arthritis patients: results of a 1-year follow-up study from the CERERRA collaboration. Ann Rheum Dis. 2012, 71: 374-377. 10.1136/annrheumdis-2011-200003.View ArticlePubMedGoogle Scholar
- Emery P, Dörner T: Optimising treatment in rheumatoid arthritis: a review of potential biological markers of response. Ann Rheum Dis. 2011, 70: 2063-2070. 10.1136/ard.2010.148015.View ArticlePubMedGoogle Scholar
- Isaacs JD, Cohen SB, Emery P, Tak PP, Wang J, Lei G, Williams S, Lal P, Read SJ: Effect of baseline rheumatoid factor and anticitrullinated peptide antibody serotype on rituximab clinical response: a meta-analysis. Ann Rheum Dis. 2013, 72: 329-336. 10.1136/annrheumdis-2011-201117.View ArticlePubMedGoogle Scholar
- van Vollenhoven RF, Emery P, Bingham CO, Keystone EC, Fleischmann R, Furst DE, Macey K, Sweetser M, Kelman A, Rao R: Long-term safety of patients receiving rituximab in rheumatoid arthritis clinical trials. J Rheum. 2010, 37: 558-567. 10.3899/jrheum.090856.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.