Volume 4 Supplement 3

The Scientific Basis of Rheumatology

Reviews

Edited by Marc Feldmann, Hideaki Nagase, Jeremy Saklatvala, Mark Walport

Funded by an unrestricted educational grant from Abbott Immunology.

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  1. Review

    Single nucleotide polymorphisms and disease gene mapping

    Single nucleotide polymorphisms are the most important and basic form of variation in the genome, and they are responsible for genetic effects that produce susceptibility to most autoimmune diseases. The rapid...

    John I Bell

    Arthritis Research & Therapy 2002 4(Suppl 3):S273

    Published on: 9 May 2002

  2. Review

    Studies of T-cell activation in chronic inflammation

    The strong association between specific alleles encoded within the MHC class II region and the development of rheumatoid arthritis (RA) has provided the best evidence to date that CD4+ T cells play a role in the ...

    Andrew P Cope

    Arthritis Research & Therapy 2002 4(Suppl 3):S197

    Published on: 9 May 2002

  3. Review

    The immunological synapse

    T-cell activation requires interaction of T-cell antigen receptors with proteins of the major histocompatibility complex (antigen). This interaction takes place in a specialized cell–cell junction referred to ...

    Michael L Dustin

    Arthritis Research & Therapy 2002 4(Suppl 3):S119

    Published on: 9 May 2002

  4. Review

    High-efficiency gene transfer into nontransformed cells: utility for studying gene regulation and analysis of potential therapeutic targets

    The elucidation of the signalling pathways involved in inflammatory diseases, such as rheumatoid arthritis, could provide long sought after targets for therapeutic intervention. Gene regulation is complex and ...

    Nicole J Horwood, Clive Smith, Evangelos Andreakos, Emilia Quattrocchi, Fionula M Brennan, Marc Feldmann and Brian MJ Foxwell

    Arthritis Research & Therapy 2002 4(Suppl 3):S215

    Published on: 9 May 2002

  5. Review

    Tissue engineering: chondrocytes and cartilage

    Tissue engineering offers new strategies for developing treatments for the repair and regeneration of damaged and diseased tissues. These treatments, using living cells, will exploit new developments in unders...

    Tim Hardingham, Simon Tew and Alan Murdoch

    Arthritis Research & Therapy 2002 4(Suppl 3):S63

    Published on: 9 May 2002

  6. Review

    Perspectives for TNF-α-targeting therapies

    Rheumatoid arthritis (RA) is the most common chronic autoimmunopathy, clinically leading to joint destruction as a consequence of the chronic inflammatory processes. The pathogenesis of this disabling disease ...

    Hanns-Martin Lorenz and Joachim R Kalden

    Arthritis Research & Therapy 2002 4(Suppl 3):S17

    Published on: 9 May 2002

  7. Review

    The paradigm of IL-6: from basic science to medicine

    IL-6 is a pleiotropic cytokine with a wide range of biological activities in immune regulation, hematopoiesis, inflammation, and oncogenesis. Its activities are shared by IL-6-related cytokines such as leukemi...

    Tetsuji Naka, Norihiro Nishimoto and Tadamitsu Kishimoto

    Arthritis Research & Therapy 2002 4(Suppl 3):S233

    Published on: 9 May 2002

  8. Review

    Genes and environment in arthritis: can RA be prevented?

    Understanding of how interactions between genes and environment contribute to the development of arthritis is a central issue in understanding the etiology of rheumatoid arthritis (RA), as well as for eventual...

    Lars Klareskog, Johnny Lorentzen, Leonid Padyukov and Lars Alfredsson

    Arthritis Research & Therapy 2002 4(Suppl 3):S31

    Published on: 9 May 2002

  9. Review

    The instructive role of dendritic cells on T-cell responses

    Immune responses are initiated in the T-cell areas of secondary lymphoid organs where naïve T lymphocytes encounter dendritic cells (DCs) that present antigens taken up in peripheral tissues. DCs represent the...

    Federica Sallusto and Antonio Lanzavecchia

    Arthritis Research & Therapy 2002 4(Suppl 3):S127

    Published on: 9 May 2002

  10. Review

    Why do we not have a cure for rheumatoid arthritis?

    There are currently unprecedented opportunities to treat rheumatoid arthritis using well-designed, highly effective, targeted therapies. This will result in a substantial improvement in the outcome of this dis...

    Hani D El-Gabalawy and Peter E Lipsky

    Arthritis Research & Therapy 2002 4(Suppl 3):S297

    Published on: 9 May 2002

  11. Review

    Signaling for survival and apoptosis in the immune system

    Signal transduction induced by tumor necrosis factor (TNF) family members and their receptors has been an intensive area of research for several years. The major impact of these studies has been the delineatio...

    Tak W Mak and Wen-Chen Yeh

    Arthritis Research & Therapy 2002 4(Suppl 3):S243

    Published on: 9 May 2002

  12. Review

    HLA-B27: natural function and pathogenic role in spondyloarthritis

    The human leukocyte antigen HLA-B27 is strongly associated with development of a group of inflammatory arthritides collectively known as the spondyloarthritides. We have set out to define the natural immunolog...

    Andrew McMichael and Paul Bowness

    Arthritis Research & Therapy 2002 4(Suppl 3):S153

    Published on: 9 May 2002

  13. Review

    Matrix metalloproteinases in arthritic disease

    The role of matrix metalloproteinases in the degradative events invoked in the cartilage and bone of arthritic joints has long been appreciated and attempts at the development of proteinase inhibitors as poten...

    Gillian Murphy, Vera Knäuper, Susan Atkinson, George Butler, William English, Mike Hutton, Jan Stracke and Ian Clark

    Arthritis Research & Therapy 2002 4(Suppl 3):S39

    Published on: 9 May 2002

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