Volume 5 Supplement 4

Targeting B cells in autoimmune diseases

Reviews

Edited by Peter E Lipsky and Ravinder N Maini

Supported by an educational grant from Roche Pharmaceuticals

  1. Review

    Targeting B cells for the treatment of rheumatoid arthritis

    The role of B cells in rheumatoid arthritis (RA) has been debated for decades. However, recent clinical trial data indicating that depletion of B cells in RA patients is of therapeutic benefit has validated th...

    Thomas J Oligino and Stacie A Dalrymple

    Arthritis Res Ther 2003 5(Suppl 4):S7

    Published on: 2 October 2003

  2. Review

    B cell depletion in autoimmune disease

    The CD20 cell marker appears early in the process of B cell development. In this review we focus on the results of attempts to utilize B cell depletion based on the use of a chimeric monoclonal antibody (MAb) ...

    Claire Gorman, Maria Leandro and David Isenberg

    Arthritis Res Ther 2003 5(Suppl 4):S17

    Published on: 2 October 2003

  3. Review

    B cell abnormalities in systemic lupus erythematosus

    Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease characterized by the differentiation of short- and long-lived immunoglobulin secreting plasma cells that secrete pathogenic autoa...

    Amrie C Grammer and Peter E Lipsky

    Arthritis Res Ther 2003 5(Suppl 4):S22

    Published on: 2 December 2003

  4. Review

    Roles of B cells in rheumatoid arthritis

    B lymphocytes play several critical roles in the pathogenesis of rheumatoid arthritis. They are the source of the rheumatoid factors and anticitrullinated protein antibodies, which contribute to immune complex...

    Gregg J Silverman and Dennis A Carson

    Arthritis Res Ther 2003 5(Suppl 4):S1

    Published on: 2 December 2003

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