Volume 8 Supplement 2

Interleukin-6, a pleiotropic cytokine

Reviews

Edited by Josef Smolen

Supported by an educational grant from Roche Pharmaceuticals

  1. Review

    Interleukin-6: discovery of a pleiotropic cytokine

    In the late 1960s, the essential role played by T cells in antibody production was reported. This led to our hypothesis that certain molecules would have to be released from T cells to effect the stimulation o...

    Tadamitsu Kishimoto

    Arthritis Research & Therapy 2006 8(Suppl 2):S2

    Published on: 28 July 2006

  2. Review

    Interleukin-6 and chronic inflammation

    Interleukin (IL)-6 is produced at the site of inflammation and plays a key role in the acute phase response as defined by a variety of clinical and biological features such as the production of acute phase pro...

    Cem Gabay

    Arthritis Research & Therapy 2006 8(Suppl 2):S3

    Published on: 28 July 2006

  3. Review

    Interleukin-6 and rheumatic diseases

    IL-6 is a pleiotropic cytokine involved in both the initiation and the maintenance of the inflammatory and immunologic responses in certain autoimmune diseases. Blocking of these two complementary functions of...

    Peter E Lipsky

    Arthritis Research & Therapy 2006 8(Suppl 2):S4

    Published on: 28 July 2006

  4. Review

    Interleukin-6: a new therapeutic target

    The therapeutic success of biological agents, especially the tumour necrosis factor (TNF) inhibitors, has opened a new chapter in the book of therapies for rheumatoid arthritis. Nevertheless, more than 50% of ...

    Josef S Smolen and Ravinder N Maini

    Arthritis Research & Therapy 2006 8(Suppl 2):S5

    Published on: 28 July 2006

    The Erratum to this article has been published in Arthritis Research & Therapy 2006 8:407