Volume 9 Supplement 2

Advances in systemic sclerosis and related fibrotic and vascular conditions

Reviews

Edited by Carol M Black, Christopher P Denton, Steffen Gay, Lars C Huber and James R Seibold

This supplement has been supported by an educational grant from Actelion Pharmaceuticals Ltd

  1. Review

    Genetic factors in systemic sclerosis

    A number of genetic loci have been identified that appear to be associated with systemic sclerosis (SSc; scleroderma). There is mounting evidence suggesting that these genetic associations may in fact be assoc...

    Maureen D Mayes and Maria Trojanowska

    Arthritis Research & Therapy 2007 9(Suppl 2):S5

    Published on: 15 August 2007

  2. Review

    Therapeutic targets in systemic sclerosis

    The precise aetiology of systemic sclerosis (SSc) remains elusive, but significant advances over the past few years have improved our understanding of the underlying pathogenic processes and identified key pat...

    Christopher P Denton

    Arthritis Research & Therapy 2007 9(Suppl 2):S6

    Published on: 15 August 2007

  3. Review

    Clinical trials in systemic sclerosis: lessons learned and outcomes

    The pathogenesis of systemic sclerosis (SSc) is complex and largely unclear. The clinical heterogeneity of the disease and its progression over a number of years makes the choice of endpoints in the design of ...

    Marco Matucci-Cerinic, Virginia D Steen, Daniel E Furst and James R Seibold

    Arthritis Research & Therapy 2007 9(Suppl 2):S7

    Published on: 15 August 2007

  4. Review

    Pulmonary hypertension associated with sarcoidosis

    Pulmonary involvement is common in sarcoidosis, an immune-mediated inflammatory disorder that is characterized by non-caseating granulomas in tissue. Sarcoid patients with advanced pulmonary disease, especiall...

    Robert P Baughman

    Arthritis Research & Therapy 2007 9(Suppl 2):S8

    Published on: 15 August 2007

  5. Review

    Vasculitis: mechanisms involved and clinical manifestations

    Systemic vasculitis, an inflammatory necrotizing disease of the blood vessel walls, can occur secondary to autoimmune diseases, including connective tissue diseases. Various pathogenic mechanisms have been imp...

    Loic Guillevin and Thomas Dörner

    Arthritis Research & Therapy 2007 9(Suppl 2):S9

    Published on: 15 August 2007