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  1. Research article

    Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis

    The inhibition of pyrimidine biosynthesis by blocking the dihydroorotate dehydrogenase (DHODH) activity, the prime target of leflunomide (LEF), has been proven to be an effective strategy for rheumatoid arthri...

    Raphael S. Peres, Gabriela B. Santos, Nerry T. Cecilio, Valquíria A. P. Jabor, Michael Niehues, Bruna G. S. Torres, Gabriela Buqui, Carlos H. T. P. Silva, Teresa Dalla Costa, Norberto P. Lopes, Maria C. Nonato, Fernando S. Ramalho, Paulo Louzada-Júnior, Thiago M. Cunha, Fernando Q. Cunha, Flavio S. Emery…

    Arthritis Research & Therapy 2017 19:47

    Published on: 7 March 2017

  2. Research article

    Epidemiology and disease characteristics of systemic sclerosis-related pulmonary arterial hypertension: results from a real-life screening programme

    Pulmonary arterial hypertension (PAH) is the leading cause of death in systemic sclerosis (SSc). Annual screening with echocardiogram (ECHO) is recommended. We present the methodological aspects of a PAH scree...

    Kathleen Morrisroe, Wendy Stevens, Joanne Sahhar, Candice Rabusa, Mandana Nikpour and Susanna Proudman

    Arthritis Research & Therapy 2017 19:42

    Published on: 7 March 2017

  3. Research article

    Effect of FCGR polymorphism on the occurrence of late-onset neutropenia and flare-free survival in rheumatic patients treated with rituximab

    The causes and mechanisms of late-onset neutropenia (LON) following rituximab treatment in patients with rheumatic diseases are not known. In this study, we aimed to investigate the role of established Fcγ rec...

    Sofia Ajeganova, Daniel Tesfa, Hans Hägglund, Bengt Fadeel, Inger Vedin, Anna Linda Zignego and Jan Palmblad

    Arthritis Research & Therapy 2017 19:44

    Published on: 7 March 2017

  4. Research article

    The impact of arthritis and joint pain on individual healthcare expenditures: findings from the Medical Expenditure Panel Survey (MEPS), 2011

    Joint pain, including back pain, and arthritis are common conditions in the United States, affecting more than 100 million individuals and costing upwards of $200 billion each year. Although activity limitatio...

    Edith M. Williams, Rebekah J. Walker, Trevor Faith and Leonard E. Egede

    Arthritis Research & Therapy 2017 19:38

    Published on: 28 February 2017

  5. Research article

    Structural cartilage damage attracts circulating rheumatoid arthritis synovial fibroblasts into affected joints

    Rheumatoid arthritis synovial fibroblasts (RASFs) are known to travel via the bloodstream from sites of cartilage destruction to new locations where they reinitiate the destructive processes at distant articul...

    Jan Hillen, Christiane Geyer, Marianne Heitzmann, Denise Beckmann, Annika Krause, Ina Winkler, Hermann Pavenstädt, Christoph Bremer, Thomas Pap and Adelheid Korb-Pap

    Arthritis Research & Therapy 2017 19:40

    Published on: 28 February 2017

  6. Research article

    Epstein-Barr virus lytic infection promotes activation of Toll-like receptor 8 innate immune response in systemic sclerosis monocytes

    Monocytes/macrophages are activated in several autoimmune diseases, including systemic sclerosis (scleroderma; SSc), with increased expression of interferon (IFN)-regulatory genes and inflammatory cytokines, s...

    Antonella Farina, Giovanna Peruzzi, Valentina Lacconi, Stefania Lenna, Silvia Quarta, Edoardo Rosato, Anna Rita Vestri, Michael York, David H. Dreyfus, Alberto Faggioni, Stefania Morrone, Maria Trojanowska and G. Alessandra Farina

    Arthritis Research & Therapy 2017 19:39

    Published on: 28 February 2017

  7. Research article

    Presence of an interferon signature in individuals who are anti-nuclear antibody positive lacking a systemic autoimmune rheumatic disease diagnosis

    Elevated levels of type I interferons (IFNs) are a characteristic feature of the systemic autoimmune rheumatic diseases (SARDs) and are thought to play an important pathogenic role. However, it is unknown whet...

    Joan Wither, Sindhu R. Johnson, Tony Liu, Babak Noamani, Dennisse Bonilla, Larissa Lisnevskaia, Earl Silverman, Arthur Bookman and Carolina Landolt-Marticorena

    Arthritis Research & Therapy 2017 19:41

    Published on: 28 February 2017

  8. Research article

    Sex differences in the association of skin advanced glycation endproducts with knee osteoarthritis progression

    The accumulation of advanced glycation endproducts in articular cartilage has been suggested as an etiologic factor in the development and progression of knee osteoarthritis (KOA).

    Charles B. Eaton, Maria Sayeed, Syeda Ameernaz, Mary B. Roberts, John D. Maynard, Jeffrey B. Driban and Timothy E. McAlindon

    Arthritis Research & Therapy 2017 19:36

    Published on: 17 February 2017

  9. Research article

    CD14brightCD16+ intermediate monocytes are induced by interleukin-10 and positively correlate with disease activity in rheumatoid arthritis

    Three different subsets of circulating human monocytes, CD14brightCD16- (classical), CD14brightCD16+ (intermediate), and CD14dimCD16+ (non-classical) have been recently identified. It has been reported that CD14b...

    Masako Tsukamoto, Noriyuki Seta, Keiko Yoshimoto, Katsuya Suzuki, Kunihiro Yamaoka and Tsutomu Takeuchi

    Arthritis Research & Therapy 2017 19:28

    Published on: 10 February 2017

  10. Research article

    Prevalence and associated factors of resting electrocardiogram abnormalities among systemic lupus erythematosus patients without cardiovascular disease

    Electrocardiogram (ECG) cardiovascular disease (CVD) abnormalities (ECG-CVD) are predictive of subsequent CVD events in the general population. Systemic lupus erythematosus (SLE) patients are vulnerable to CVD...

    Hanan Al Rayes, Paula J. Harvey, Dafna D. Gladman, Jiandong Su, Arthy Sabapathy, Murray B. Urowitz and Zahi Touma

    Arthritis Research & Therapy 2017 19:31

    Published on: 10 February 2017

  11. Commentary

    Latin-American challenges and opportunities in rheumatology

    The importance of diseases to mankind is very similar worldwide. However, social and environmental issues, not to mention political and individual aspects, affect the prevalence and management of diseases and ...

    Francisco Airton Castro Rocha

    Arthritis Research & Therapy 2017 19:29

    Published on: 10 February 2017

  12. Research article

    Development of three-dimensional prints of arthritic joints for supporting patients’ awareness to structural damage

    Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) result in severe joint destruction and functional disability if left untreated. We aim to develop tools that help patients with RA and PsA to understand ...

    Arnd Kleyer, Laura Beyer, Christoph Simon, Fabian Stemmler, Matthias Englbrecht, Christian Beyer, Jürgen Rech, Bernhard Manger, Gerhard Krönke, Georg Schett and Axel J. Hueber

    Arthritis Research & Therapy 2017 19:34

    Published on: 10 February 2017

  13. Research article

    Endothelial injury in rheumatoid arthritis: a crosstalk between dimethylarginines and systemic inflammation

    Symmetric (SDMA) and asymmetric (ADMA) dimethylarginines have emerged as novel biomarkers of cardiovascular disease (CVD) in several disease settings associated with atherosclerosis. Rheumatoid arthritis (RA) ...

    Theodoros Dimitroulas, James Hodson, Aamer Sandoo, Jacqueline Smith and George D. Kitas

    Arthritis Research & Therapy 2017 19:32

    Published on: 10 February 2017

  14. Research article

    Th17 and CD24hiCD27+ regulatory B lymphocytes are biomarkers of response to biologics in rheumatoid arthritis

    The aim was to describe the regulatory B and T cells (Breg and Treg) and T helper 17 (Th17) lymphocytes before and under treatment with biologic drugs, and to assess their potential predictive value as biomark...

    Sarah Salomon, Caroline Guignant, Pierre Morel, Gauthier Flahaut, Clément Brault, Clément Gourguechon, Patrice Fardellone, Jean-Pierre Marolleau, Brigitte Gubler and Vincent Goëb

    Arthritis Research & Therapy 2017 19:33

    Published on: 10 February 2017

  15. Research article

    Priming in response to pro-inflammatory cytokines is a feature of adult synovial but not dermal fibroblasts

    It has been hypothesized that chronic inflammatory diseases such as rheumatoid arthritis (RA) may be caused by a failure of negative feedback mechanisms. This study sought to examine negative feedback mechanis...

    Thomas Crowley, John D. O’Neil, Holly Adams, Andrew M. Thomas, Andrew Filer, Christopher D. Buckley and Andrew R. Clark

    Arthritis Research & Therapy 2017 19:35

    Published on: 10 February 2017

  16. Research article

    Ultrasound-detected pathologies cluster into groups with different clinical outcomes: data from 3000 community referrals for shoulder pain

    Ultrasound is increasingly used to evaluate shoulder pain, but the benefits of this are unclear. In this study, we examined whether ultrasound-defined pathologies have implications for clinical outcomes.

    Gui Tran, Elizabeth M. A. Hensor, Aaron Ray, Sarah R. Kingsbury, Philip O’Connor and Philip G. Conaghan

    Arthritis Research & Therapy 2017 19:30

    Published on: 10 February 2017

  17. Research article

    Fat mass and fat distribution are associated with low back pain intensity and disability: results from a cohort study

    Determining the association between body composition and low back pain (LBP) will improve our understanding of the mechanisms by which obesity affects LBP, and inform novel approaches to managing LBP. The aim ...

    Sultana Monira Hussain, Donna M. Urquhart, Yuanyuan Wang, Jonathan E. Shaw, Dianna J. Magliano, Anita E. Wluka and Flavia M. Cicuttini

    Arthritis Research & Therapy 2017 19:26

    Published on: 10 February 2017

  18. Research article

    Proangiogenic effects of soluble α-Klotho on systemic sclerosis dermal microvascular endothelial cells

    Systemic sclerosis (SSc) is characterized by endothelial cell (EC) apoptosis, impaired angiogenesis and peripheral microvasculopathy. Soluble α-Klotho (sKl) is a pleiotropic molecule with multiple effects on E...

    Celestina Mazzotta, Mirko Manetti, Irene Rosa, Eloisa Romano, Jelena Blagojevic, Silvia Bellando-Randone, Cosimo Bruni, Gemma Lepri, Serena Guiducci, Lidia Ibba-Manneschi and Marco Matucci-Cerinic

    Arthritis Research & Therapy 2017 19:27

    Published on: 10 February 2017

  19. Research article

    Circulating plasmablasts/plasma cells: a potential biomarker for IgG4-related disease

    Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is a multisystem fibroinflammatory disease. We previously reported that a circulating cell population expressing CD19+CD24CD38hi was increased in patients with ...

    Wei Lin, Panpan Zhang, Hua Chen, Yu Chen, Hongxian Yang, Wenjie Zheng, Xuan Zhang, Fengxiao Zhang, Wen Zhang and Peter E. Lipsky

    Arthritis Research & Therapy 2017 19:25

    Published on: 10 February 2017

  20. Research article

    Osteoarthritis-associated basic calcium phosphate crystals activate membrane proximal kinases in human innate immune cells

    Osteoarthritis (OA) is a chronic debilitating joint disorder of particularly high prevalence in the elderly population. Intra-articular basic calcium phosphate (BCP) crystals are present in the majority of OA ...

    Emma M. Corr, Clare C. Cunningham, Laura Helbert, Geraldine M. McCarthy and Aisling Dunne

    Arthritis Research & Therapy 2017 19:23

    Published on: 7 February 2017

  21. Research article

    α2AP regulates vascular alteration by inhibiting VEGF signaling in systemic sclerosis: the roles of α2AP in vascular dysfunction in systemic sclerosis

    Systemic sclerosis (SSc) is a connective tissues disease of unknown origin characterized by vascular damage and extensive fibrosis. Recently, we demonstrated that α2-antiplasmin (α2AP) is associated with the d...

    Yosuke Kanno, En Shu, Hiroyuki Kanoh, Ayaka Matsuda and Mariko Seishima

    Arthritis Research & Therapy 2017 19:22

    Published on: 3 February 2017

  22. Research article

    Discovery of new candidate genes for rheumatoid arthritis through integration of genetic association data with expression pathway analysis

    Here we integrate verified signals from previous genetic association studies with gene expression and pathway analysis for discovery of new candidate genes and signaling networks, relevant for rheumatoid arthr...

    Klementy Shchetynsky, Lina-Marcella Diaz-Gallo, Lasse Folkersen, Aase Haj Hensvold, Anca Irinel Catrina, Louise Berg, Lars Klareskog and Leonid Padyukov

    Arthritis Research & Therapy 2017 19:19

    Published on: 2 February 2017

  23. Research article

    A longitudinal study of fecal calprotectin and the development of inflammatory bowel disease in ankylosing spondylitis

    Patients with ankylosing spondylitis (AS) are at increased risk of developing inflammatory bowel disease (IBD). We aimed to determine the variation in fecal calprotectin in AS over 5 years in relation to disea...

    Eva Klingberg, Hans Strid, Arne Ståhl, Anna Deminger, Hans Carlsten, Lena Öhman and Helena Forsblad-d’Elia

    Arthritis Research & Therapy 2017 19:21

    Published on: 2 February 2017

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