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  1. Research article

    Doctors’ preferences in de-escalating DMARDs in rheumatoid arthritis: a discrete choice experiment

    Current guidelines suggest reduction of DMARDs can be considered in RA patients in remission. Objectives were (1) to estimate the relative importance of patient characteristics rheumatologists consider in thei...

    T. Martijn Kuijper, Riëtte Folmer, Elly A. Stolk, Johanna M. W. Hazes and Jolanda J. Luime

    Arthritis Research & Therapy 2017 19:78

    Published on: 26 April 2017

  2. Research article

    Incorporating assessment of the cervical facet joints in the modified Stoke ankylosing spondylitis spine score is of additional value in the evaluation of spinal radiographic outcome in ankylosing spondylitis

    To aim was to investigate the additional value of incorporating the de Vlam cervical facet joint score in the modified ankylosing spondylitis (AS) spine score (mSASSS) for the evaluation of spinal radiographic...

    Fiona Maas, Suzanne Arends, Elisabeth Brouwer, Hendrika Bootsma, Reinhard Bos, Freke R. Wink and Anneke Spoorenberg

    Arthritis Research & Therapy 2017 19:77

    Published on: 26 April 2017

  3. Research article

    Baseline JAK phosphorylation profile of peripheral blood leukocytes, studied by whole blood phosphospecific flow cytometry, is associated with 1-year treatment response in early rheumatoid arthritis

    We found recently that baseline signal transducer and activator of transcription 3 phosphorylation in peripheral blood CD4+ T cells of patients with early rheumatoid arthritis (RA) is associated with treatment re...

    Krista Kuuliala, Antti Kuuliala, Riitta Koivuniemi, Hannu Kautiainen, Heikki Repo and Marjatta Leirisalo-Repo

    Arthritis Research & Therapy 2017 19:75

    Published on: 11 April 2017

  4. Research article

    Glutaminase 1 plays a key role in the cell growth of fibroblast-like synoviocytes in rheumatoid arthritis

    The recent findings of cancer-specific metabolic changes, including increased glucose and glutamine consumption, have provided new therapeutic targets for consideration. Fibroblast-like synoviocytes (FLS) from...

    Soshi Takahashi, Jun Saegusa, Sho Sendo, Takaichi Okano, Kengo Akashi, Yasuhiro Irino and Akio Morinobu

    Arthritis Research & Therapy 2017 19:76

    Published on: 11 April 2017

  5. Research article

    Direct-acting antiviral agents in the therapy of hepatitis C virus-related mixed cryoglobulinaemia: a single-centre experience

    The efficacy and safety of direct-acting antiviral agents (DAAs) were evaluated in a cohort of prospectively enrolled patients with hepatitis C virus (HCV)-related mixed cryoglobulinaemia (MC), an immune compl...

    Gianfranco Lauletta, Sabino Russi, Fabio Pavone, Angelo Vacca and Franco Dammacco

    Arthritis Research & Therapy 2017 19:74

    Published on: 8 April 2017

  6. Research article

    Diagnostic value of a 3-day course of prednisolone in patients with possible rheumatoid arthritis – the TryCort study

    In patients with tender and swollen finger joints, the differential diagnosis between rheumatoid arthritis (RA) and osteoarthritis (OA) of the hands can be initially difficult. This prospective study (the TryC...

    Uta Kiltz, Christine von Zabern, Xenofon Baraliakos, Frank Heldmann, Bernd Mintrop, Michael Sarholz, Dietmar Krause, Friedrich Dybowski, Ludwig Kalthoff and Jürgen Braun

    Arthritis Research & Therapy 2017 19:73

    Published on: 7 April 2017

  7. Research article

    Minimal disease activity and impact of disease in psoriatic arthritis: a Spanish cross-sectional multicenter study

    Patients with psoriatic arthritis (PsA) experience functional impairment and reduced quality of life, and thus patient global assessment in PsA is explained mainly by the physical, but also by the psychologica...

    Rubén Queiro, Juan D. Cañete, Carlos Montilla, Miguel Abad, María Montoro, Susana Gómez and Ana Cábez

    Arthritis Research & Therapy 2017 19:72

    Published on: 29 March 2017

  8. Research article

    Excessive activation of the TLR9/TGF-β1/PDGF-B pathway in the peripheral blood of patients with systemic lupus erythematosus

    Our aim is to study the existence of the TLR9/TGF-β1/PDGF-B pathway in healthy humans and patients with systemic lupus erythematosus (SLE), and to explore its possible involvement in the pathogenesis of lupus ...

    Yi Yuan, Mingyue Yang, Kuo Wang, Jing Sun, Lili Song, Xue Diao, Zhenyu Jiang, Genhong Cheng and Xiaosong Wang

    Arthritis Research & Therapy 2017 19:70

    Published on: 29 March 2017

  9. Research article

    DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis

    Multiple factors, including interactions between genetic and environmental risks, are important in susceptibility to rheumatoid arthritis (RA). However, the underlying mechanism is not fully understood. This s...

    Weida Meng, Zaihua Zhu, Xia Jiang, Chun Lai Too, Steffen Uebe, Maja Jagodic, Ingrid Kockum, Shahnaz Murad, Luigi Ferrucci, Lars Alfredsson, Hejian Zou, Lars Klareskog, Andrew P. Feinberg, Tomas J. Ekström, Leonid Padyukov and Yun Liu

    Arthritis Research & Therapy 2017 19:71

    Published on: 29 March 2017

  10. Research article

    OX40 signaling is involved in the autoactivation of CD4+CD28 T cells and contributes to the pathogenesis of autoimmune arthritis

    CD4+CD28 T cells exhibit autoreactive potential in autoimmune disorders, including rheumatoid arthritis (RA). It is not well known which costimulator functions as an alternative second signal in the activation o...

    Juean Jiang, Cuiping Liu, Mi Liu, Yu Shen, Xiaohan Hu, Qin Wang, Jian Wu, Min Wu, Qi Fang and Xueguang Zhang

    Arthritis Research & Therapy 2017 19:67

    Published on: 21 March 2017

  11. Research article

    B cell epitope of human cytomegalovirus phosphoprotein 65 (HCMV pp65) induced anti-dsDNA antibody in BALB/c mice

    HCMV phosphoprotein 65 (HCMVpp65) is a putative immunogen that acts as an accelerator, inducing autoantibody and exacerbating autoimmune response in susceptible animals. The immunity to pp65336-439 instigates aut...

    Ao HoHsieh, Chin Man Wang, Yeong-Jian Jan Wu, Albert Chen, Ming-I Chang and Ji-Yih Chen

    Arthritis Research & Therapy 2017 19:65

    Published on: 21 March 2017

  12. Research article

    Varying the item format improved the range of measurement in patient-reported outcome measures assessing physical function

    Physical function (PF) is a core patient-reported outcome domain in clinical trials in rheumatic diseases. Frequently used PF measures have ceiling effects, leading to large sample size requirements and low se...

    Gregor Liegl, Barbara Gandek, H. Felix Fischer, Jakob B. Bjorner, John E. Ware, Matthias Rose, James F. Fries and Sandra Nolte

    Arthritis Research & Therapy 2017 19:66

    Published on: 21 March 2017

  13. Research article

    Risk factors for flare and treatment of disease flares during pregnancy in rheumatoid arthritis and axial spondyloarthritis patients

    During pregnancy, patients with rheumatoid arthritis (RA) and axial spondyloarthritis (axSpA) can experience active disease, which might be influenced by adjustment of treatment around conception. The aim of t...

    Stephanie van den Brandt, Astrid Zbinden, Dominique Baeten, Peter M. Villiger, Monika Østensen and Frauke Förger

    Arthritis Research & Therapy 2017 19:64

    Published on: 20 March 2017

  14. Research article

    Subclinical dermal involvement is detectable by high frequency ultrasound even in patients with limited cutaneous systemic sclerosis

    The aim of the study was to detect by skin high-frequency ultrasound (US) possible subclinical skin involvement in patients affected by limited cutaneous systemic sclerosis (lcSSc), in those skin areas apparen...

    A. Sulli, B. Ruaro, V. Smith, S. Paolino, C. Pizzorni, G. Pesce and M. Cutolo

    Arthritis Research & Therapy 2017 19:61

    Published on: 20 March 2017

  15. Research article

    Increased serum levels of fractalkine and mobilisation of CD34+CD45 endothelial progenitor cells in systemic sclerosis

    The disruption of endothelial homeostasis is a major determinant in the pathogenesis of systemic sclerosis (SSc) and is reflected by soluble and cellular markers of activation, injury and repair. We aimed to p...

    Audrey Benyamine, Jérémy Magalon, Sylvie Cointe, Romaric Lacroix, Laurent Arnaud, Nathalie Bardin, Pascal Rossi, Yves Francès, Fanny Bernard-Guervilly, Gilles Kaplanski, Jean-Robert Harlé, Pierre-Jean Weiller, Philippe Berbis, David Braunstein, Elisabeth Jouve, Nathalie Lesavre…

    Arthritis Research & Therapy 2017 19:60

    Published on: 20 March 2017

  16. Research article

    Association of the lupus low disease activity state (LLDAS) with health-related quality of life in a multinational prospective study

    Systemic lupus erythematosus (SLE) is associated with significant impairment of health-related quality of life (HR-QoL). Recently, meeting a definition of a lupus low disease activity state (LLDAS), analogous ...

    Vera Golder, Rangi Kandane-Rathnayake, Alberta Yik-Bun Hoi, Molla Huq, Worawit Louthrenoo, Yuan An, Zhan Guo Li, Shue Fen Luo, Sargunan Sockalingam, Chak Sing Lau, Mo Yin Mok, Aisha Lateef, Kate Franklyn, Susan Morton, Sandra Teresa V. Navarra, Leonid Zamora…

    Arthritis Research & Therapy 2017 19:62

    Published on: 20 March 2017

  17. Research article

    Accuracy of magnetic resonance imaging to detect cartilage loss in severe osteoarthritis of the first carpometacarpal joint: comparison with histological evaluation

    Magnetic resonance imaging (MRI) is increasingly used for research in hand osteoarthritis, but imaging the thin cartilage layers in the hand joints remains challenging. We therefore assessed the accuracy of MR...

    Michael S. Saltzherr, J. Henk Coert, Ruud W. Selles, Johan W. van Neck, Jean-Bart Jaquet, Gerjo J. V. M. van Osch, Edwin H. G. Oei, Jolanda J. Luime and Galied S. R. Muradin

    Arthritis Research & Therapy 2017 19:55

    Published on: 14 March 2017

  18. Research article

    Chromatin landscapes and genetic risk for juvenile idiopathic arthritis

    The transcriptomes of peripheral blood cells in children with juvenile idiopathic arthritis (JIA) have distinct transcriptional aberrations that suggest impairment of transcriptional regulation. To gain a bett...

    Lisha Zhu, Kaiyu Jiang, Karstin Webber, Laiping Wong, Tao Liu, Yanmin Chen and James N. Jarvis

    Arthritis Research & Therapy 2017 19:57

    Published on: 14 March 2017

  19. Research article

    Activation status of mucosal-associated invariant T cells reflects disease activity and pathology of systemic lupus erythematosus

    Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes constituting a large proportion of peripheral blood T cells expressing αβ T-cell receptor in humans. In this study, we aimed to investiga...

    Asako Chiba, Naoto Tamura, Kazunori Yoshikiyo, Goh Murayama, Mie Kitagaichi, Ken Yamaji, Yoshinari Takasaki and Sachiko Miyake

    Arthritis Research & Therapy 2017 19:58

    Published on: 14 March 2017

  20. Research article

    Low disease activity for up to 3 years after adalimumab discontinuation in patients with early rheumatoid arthritis: 2-year results of the HOPEFUL-3 Study

    This study was conducted to evaluate the feasibility of long-term adalimumab (ADA) discontinuation after achievement of low disease activity (LDA) in Japanese patients with early rheumatoid arthritis (RA) and ...

    Yoshiya Tanaka, Hisashi Yamanaka, Naoki Ishiguro, Nobuyuki Miyasaka, Katsuyoshi Kawana, Junko Kimura, Naoki Agata and Tsutomu Takeuchi

    Arthritis Research & Therapy 2017 19:56

    Published on: 14 March 2017

  21. Research article

    Support for phosphoinositol 3 kinase and mTOR inhibitors as treatment for lupus using in-silico drug-repurposing analysis

    Systemic lupus erythematosus (SLE) is an autoimmune disease with few treatment options. Current therapies are not fully effective and show highly variable responses. In this regard, large efforts have focused ...

    Daniel Toro-Domínguez, Pedro Carmona-Sáez and Marta E. Alarcón-Riquelme

    Arthritis Research & Therapy 2017 19:54

    Published on: 11 March 2017

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