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  1. Research article

    RANK/RANKL/OPG system in the intervertebral disc

    The receptor activator of NF-κB ligand (RANKL), a member of the TNF ligand superfamily, is known to regulate bone metabolism. The expression of each component of the RANK/RANKL/osteoprotegerin (OPG) system in ...

    Norihiko Takegami, Koji Akeda, Junichi Yamada, Tomohiko Sano, Koichiro Murata, Jenny Huang, Koichi Masuda and Akihiro Sudo

    Arthritis Research & Therapy 2017 19:121

    Published on: 2 June 2017

  2. Research article

    Increased serum concentrations of IL-1 beta, IL-21 and Th17 cells in overweight patients with rheumatoid arthritis

    Obesity is associated with worse disease activity and drug responses in patients with rheumatoid arthritis (RA). However, the immunological mechanisms responsible for the relationship between RA and obesity ha...

    Hirofumi Shoda, Yasuo Nagafuchi, Yumi Tsuchida, Keiichi Sakurai, Shuji Sumitomo, Keishi Fujio and Kazuhiko Yamamoto

    Arthritis Research & Therapy 2017 19:111

    Published on: 31 May 2017

  3. Research article

    Prediction of response to remission induction therapy by gene expression profiling of peripheral blood in Japanese patients with microscopic polyangiitis

    Microscopic polyangiitis (MPA), which is classified as an anti-neutrophil cytoplasmic antibody (ANCA)-associated small vessel vasculitis, is one of the most frequent primary vasculitides in Japan. We earlier n...

    Akihiro Ishizu, Utano Tomaru, Sakiko Masuda, Ken-ei Sada, Koichi Amano, Masayoshi Harigai, Yasushi Kawaguchi, Yoshihiro Arimura, Kunihiro Yamagata, Shoichi Ozaki, Hiroaki Dobashi, Sakae Homma, Yasunori Okada, Hitoshi Sugiyama, Joichi Usui, Naotake Tsuboi…

    Arthritis Research & Therapy 2017 19:117

    Published on: 31 May 2017

  4. Research article

    Is the current ASAS expert definition of a positive family history useful in identifying axial spondyloarthritis? Results from the SPACE and DESIR cohorts

    The Assessment of SpondyloArthritis international Society (ASAS) definition of a positive family history (PFH) of spondyloarthritis (SpA) includes the following diseases in first- or second-degree relatives: a...

    Zineb Ez-Zaitouni, Andrea Hilkens, Laure Gossec, Inger Jorid Berg, Robert Landewé, Roberta Ramonda, Maxime Dougados, Désirée van der Heijde and Floris van Gaalen

    Arthritis Research & Therapy 2017 19:118

    Published on: 31 May 2017

  5. Research article

    Exosomal amyloid A and lymphatic vessel endothelial hyaluronic acid receptor-1 proteins are associated with disease activity in rheumatoid arthritis

    Exosomes are thought to play an important role in exchanging information between cells. The proteins and lipids in exosomes play roles in mediating inflammatory and autoimmune diseases. The aim of this study w...

    Jihyung Yoo, Sang Kwang Lee, Mikyung Lim, Donghyuk Sheen, Eun-Hye Choi and Soon Ae Kim

    Arthritis Research & Therapy 2017 19:119

    Published on: 31 May 2017

  6. Research article

    The prevalence of ACPA is lower in rheumatoid arthritis patients with an older age of onset but the composition of the ACPA response appears identical

    Rheumatoid arthritis (RA) consists of two syndromes, one autoantibody-positive and one autoantibody-negative. Existing data on the relation between age of onset and prevalence of autoantibodies were conflictin...

    Debbie M. Boeters, Lukas Mangnus, Sofia Ajeganova, Elisabet Lindqvist, Björn Svensson, René E. M. Toes, Leendert A. Trouw, Tom W. J. Huizinga, Francis Berenbaum, Jacques Morel, Solbritt Rantapää-Dahlqvist and Annette H. M. van der Helm-van Mil

    Arthritis Research & Therapy 2017 19:115

    Published on: 31 May 2017

  7. Research article

    In-vivo monitoring of anti-folate therapy in arthritic rats using [18F]fluoro-PEG-folate and positron emission tomography

    Folate receptor β (FRβ) is involved in facilitating cellular uptake of folates and anti-folates (such as methotrexate (MTX)). In rheumatoid arthritis, FRβ is expressed on synovial macrophages and recently has ...

    Durga M. S. H. Chandrupatla, Gerrit Jansen, Ricardo Vos, Mariska Verlaan, Qingshou Chen, Philip S. Low, Albert D. Windhorst, Adriaan A. Lammertsma, Conny J. van der Laken and Carla F. M. Molthoff

    Arthritis Research & Therapy 2017 19:114

    Published on: 31 May 2017

  8. Research article

    HDL cholesterol efflux capacity in rheumatoid arthritis patients: contributing factors and relationship with subclinical atherosclerosis

    Lipid profiles appear to be altered in rheumatoid arthritis (RA) patients because of disease activity and inflammation. Cholesterol efflux capacity (CEC), which is the ability of high-density lipoprotein chole...

    Beatriz Tejera-Segura, María Macía-Díaz, José David Machado, Antonia de Vera-González, Jose A. García-Dopico, José M. Olmos, José L. Hernández, Federico Díaz-González, Miguel A. González-Gay and Iván Ferraz-Amaro

    Arthritis Research & Therapy 2017 19:113

    Published on: 31 May 2017

  9. Research article

    Lymphatic delivery of etanercept via nanotopography improves response to collagen-induced arthritis

    Evidence suggests lymphatic function mediates local rheumatoid arthritis (RA) flares. Yet biologics that target the immune system are dosed systemically via the subcutaneous (SC) administration route, thereby ...

    Melissa B. Aldrich, Fred C. Velasquez, Sunkuk Kwon, Ali Azhdarinia, Kenneth Pinkston, Barrett R. Harvey, Wenyaw Chan, John C. Rasmussen, Russell F. Ross, Caroline E. Fife and E. M. Sevick-Muraca

    Arthritis Research & Therapy 2017 19:116

    Published on: 31 May 2017

  10. Research article

    TGFβ1-induced SMAD2/3 and SMAD1/5 phosphorylation are both ALK5-kinase-dependent in primary chondrocytes and mediated by TAK1 kinase activity

    Dysregulated transforming growth factor β (TGFβ) signaling is implicated in osteoarthritis development, making normalizing TGFβ signaling a possible therapy. Theoretically, this can be achieved with small mole...

    Arjan van Caam, Wojciech Madej, Amaya Garcia de Vinuesa, Marie-José Goumans, Peter ten Dijke, Esmeralda Blaney Davidson and Peter van der Kraan

    Arthritis Research & Therapy 2017 19:112

    Published on: 31 May 2017

  11. Research article

    Ultrasound-detected bone erosion is a relapse risk factor after discontinuation of biologic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis whose ultrasound power Doppler synovitis activity and clinical disease activity are well controlled

    In the present study, we explored the risk factors for relapse after discontinuation of biologic disease-modifying antirheumatic drug (bDMARD) therapy in patients with rheumatoid arthritis (RA) whose ultrasoun...

    Shin-ya Kawashiri, Keita Fujikawa, Ayako Nishino, Akitomo Okada, Toshiyuki Aramaki, Toshimasa Shimizu, Masataka Umeda, Shoichi Fukui, Takahisa Suzuki, Tomohiro Koga, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Akinari Mizokami, Hideki Nakamura, Tomoki Origuchi…

    Arthritis Research & Therapy 2017 19:108

    Published on: 25 May 2017

  12. Research article

    Pregnancy-induced gene expression changes in vivo among women with rheumatoid arthritis: a pilot study

    Little is known about gene expression changes induced by pregnancy in women with rheumatoid arthritis (RA) and healthy women because the few studies previously conducted did not have pre-pregnancy samples avai...

    Dana E. Goin, Mette Kiel Smed, Lior Pachter, Elizabeth Purdom, J. Lee Nelson, Hanne Kjærgaard, Jørn Olsen, Merete Lund Hetland, Vibeke Zoffmann, Bent Ottesen and Damini Jawaheer

    Arthritis Research & Therapy 2017 19:104

    Published on: 25 May 2017

  13. Research article

    Early blockade of joint inflammation with a fatty acid amide hydrolase inhibitor decreases end-stage osteoarthritis pain and peripheral neuropathy in mice

    The endocannabinoid system has been shown to reduce inflammatory flares and pain in rodent models of arthritis. A limitation of endocannabinoids is that they are rapidly denatured by hydrolysing enzymes such a...

    Jason J. McDougall, Milind M. Muley, Holly T. Philpott, Allison Reid and Eugene Krustev

    Arthritis Research & Therapy 2017 19:106

    Published on: 25 May 2017

  14. Research article

    Pre-silencing of genes involved in the electron transport chain (ETC) pathway is associated with responsiveness to abatacept in rheumatoid arthritis

    In the current context of personalized medicine, one of the major challenges in the management of rheumatoid arthritis (RA) is to identify biomarkers that predict drug responsiveness. From the European APPRAIS...

    C. Derambure, G. Dzangue-Tchoupou, C. Berard, N. Vergne, M. Hiron, M. A. D’Agostino, P. Musette, O. Vittecoq and T. Lequerré

    Arthritis Research & Therapy 2017 19:109

    Published on: 25 May 2017

  15. Research article

    Tie2 as a novel key factor of microangiopathy in systemic sclerosis

    The angiopoietin(Ang)/Tie2 system is a key regulator of vascular biology. The expression of membrane bound (mb) Tie2 and Ang-1 ensures vessel stability, whereas Ang-2, inducible by vascular endothelial growth ...

    Falk Moritz, Janine Schniering, Jörg H. W. Distler, Renate E. Gay, Steffen Gay, Oliver Distler and Britta Maurer

    Arthritis Research & Therapy 2017 19:105

    Published on: 25 May 2017

  16. Research article

    Differences in serum and synovial CD4+ T cells and cytokine profiles to stratify patients with inflammatory osteoarthritis and rheumatoid arthritis

    The aim was to investigate CD4+T-cell subsets, immune cells and their cytokine profiles in blood and synovial compartments in rheumatoid arthritis (RA) and inflammatory osteoarthritis (OA) to define specific immu...

    Alessandra Penatti, Federica Facciotti, Roberta De Matteis, Paola Larghi, Moira Paroni, Antonella Murgo, Orazio De Lucia, Massimiliano Pagani, Luca Pierannunzii, Marcello Truzzi, Andreea Ioan-Facsinay, Sergio Abrignani, Jens Geginat and Pier Luigi Meroni

    Arthritis Research & Therapy 2017 19:103

    Published on: 19 May 2017

  17. Research article

    B cell repopulation kinetics after rituximab treatment in ANCA-associated vasculitides compared to rheumatoid arthritis, and connective tissue diseases: a longitudinal observational study on 120 patients

    B cell depletion with rituximab (RTX) is approved for treatment of rheumatoid arthritis (RA) and ANCA-associated vasculitides (AAV). Recently, RTX has been shown to be effective in AAV maintenance therapy, but...

    Jens Thiel, Marta Rizzi, Marie Engesser, Ann-Kathrin Dufner, Arianna Troilo, Raquel Lorenzetti, Reinhard E. Voll and Nils Venhoff

    Arthritis Research & Therapy 2017 19:101

    Published on: 18 May 2017

  18. Research article

    TNF inhibitors appear to inhibit disease progression and improve outcome in Takayasu arteritis; an observational, population-based time trend study

    Magnetic resonance imaging (MRI) and computed tomography (CT) angiography have now largely replaced interventional angiography in the diagnoses and follow up of Takayasu arteritis (TAK) but data on the effects...

    Birgir Gudbrandsson, Øyvind Molberg and Øyvind Palm

    Arthritis Research & Therapy 2017 19:99

    Published on: 18 May 2017

  19. Research article

    M2 macrophage is the predominant phenotype in airways inflammatory lesions in patients with granulomatosis with polyangiitis

    Macrophages may present two distinct phenotypes indicated as M1 and M2 under different stimuli. M1 and M2 macrophages have divergent functions that range from enhancement of inflammation for M1 to tissue repai...

    Alexandre Wagner Silva de Souza, Mirjan van Timmeren, Jan-Stephan Sanders, Coen Stegeman, Peter Heeringa, Cees G. M. Kallenberg and Johanna Westra

    Arthritis Research & Therapy 2017 19:100

    Published on: 18 May 2017

  20. Research article

    Are ankylosing spondylitis, psoriatic arthritis and undifferentiated spondyloarthritis associated with an increased risk of cardiovascular events? A prospective nationwide population-based cohort study

    To investigate the risk of first-time acute coronary syndrome (ACS), stroke and venous thromboembolism (VTE) in patients with ankylosing spondylitis (AS), psoriatic arthritis (PsA) and undifferentiated spondyl...

    Karin Bengtsson, Helena Forsblad-d’Elia, Elisabeth Lie, Eva Klingberg, Mats Dehlin, Sofia Exarchou, Ulf Lindström, Johan Askling and Lennart T. H. Jacobsson

    Arthritis Research & Therapy 2017 19:102

    Published on: 18 May 2017

  21. Research article

    Associations between systemic bone mineral density and early knee cartilage changes in middle-aged adults without clinical knee disease: a prospective cohort study

    Osteoarthritis has a high prevalence in people with high bone mineral density (BMD). Nevertheless, whether high systemic BMD predates early structural features of knee osteoarthritis is unclear. This study exa...

    Andrew J. Teichtahl, Yuanyuan Wang, Anita E. Wluka, Boyd J. Strauss, Joseph Proietto, John B. Dixon, Graeme Jones and Flavia M. Cicuttini

    Arthritis Research & Therapy 2017 19:98

    Published on: 18 May 2017

  22. Research article

    The performance of different classification criteria sets for spondyloarthritis in the worldwide ASAS-COMOSPA study

    In this study, we sought to compare the performance of spondyloarthritis (SpA) classification criteria sets in an international SpA cohort with patients included from five continents around the world.

    Pauline Bakker, Anna Moltó, Adrien Etcheto, Filip Van den Bosch, Robert Landewé, Floris van Gaalen, Maxime Dougados and Désirée van der Heijde

    Arthritis Research & Therapy 2017 19:96

    Published on: 16 May 2017

  23. Research article

    Interleukin-10-producing LAG3+ regulatory T cells are associated with disease activity and abatacept treatment in rheumatoid arthritis

    Regulatory T cells (Tregs) play a role in the suppression of inflammation in autoimmune diseases, and lymphocyte activation gene 3 (LAG3) was reported as a marker of interleukin (IL)-10-producing Tregs. We aim...

    Shinichiro Nakachi, Shuji Sumitomo, Yumi Tsuchida, Haruka Tsuchiya, Masanori Kono, Rika Kato, Keiichi Sakurai, Norio Hanata, Yasuo Nagafuchi, Shoko Tateishi, Hiroko Kanda, Tomohisa Okamura, Kazuhiko Yamamoto and Keishi Fujio

    Arthritis Research & Therapy 2017 19:97

    Published on: 16 May 2017

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