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  1. Research article

    OX40 signaling is involved in the autoactivation of CD4+CD28 T cells and contributes to the pathogenesis of autoimmune arthritis

    CD4+CD28 T cells exhibit autoreactive potential in autoimmune disorders, including rheumatoid arthritis (RA). It is not well known which costimulator functions as an alternative second signal in the activation o...

    Juean Jiang, Cuiping Liu, Mi Liu, Yu Shen, Xiaohan Hu, Qin Wang, Jian Wu, Min Wu, Qi Fang and Xueguang Zhang

    Arthritis Research & Therapy 2017 19:67

    Published on: 21 March 2017

  2. Research article

    B cell epitope of human cytomegalovirus phosphoprotein 65 (HCMV pp65) induced anti-dsDNA antibody in BALB/c mice

    HCMV phosphoprotein 65 (HCMVpp65) is a putative immunogen that acts as an accelerator, inducing autoantibody and exacerbating autoimmune response in susceptible animals. The immunity to pp65336-439 instigates aut...

    Ao HoHsieh, Chin Man Wang, Yeong-Jian Jan Wu, Albert Chen, Ming-I Chang and Ji-Yih Chen

    Arthritis Research & Therapy 2017 19:65

    Published on: 21 March 2017

  3. Research article

    Varying the item format improved the range of measurement in patient-reported outcome measures assessing physical function

    Physical function (PF) is a core patient-reported outcome domain in clinical trials in rheumatic diseases. Frequently used PF measures have ceiling effects, leading to large sample size requirements and low se...

    Gregor Liegl, Barbara Gandek, H. Felix Fischer, Jakob B. Bjorner, John E. Ware, Matthias Rose, James F. Fries and Sandra Nolte

    Arthritis Research & Therapy 2017 19:66

    Published on: 21 March 2017

  4. Research article

    Risk factors for flare and treatment of disease flares during pregnancy in rheumatoid arthritis and axial spondyloarthritis patients

    During pregnancy, patients with rheumatoid arthritis (RA) and axial spondyloarthritis (axSpA) can experience active disease, which might be influenced by adjustment of treatment around conception. The aim of t...

    Stephanie van den Brandt, Astrid Zbinden, Dominique Baeten, Peter M. Villiger, Monika Østensen and Frauke Förger

    Arthritis Research & Therapy 2017 19:64

    Published on: 20 March 2017

  5. Research article

    Subclinical dermal involvement is detectable by high frequency ultrasound even in patients with limited cutaneous systemic sclerosis

    The aim of the study was to detect by skin high-frequency ultrasound (US) possible subclinical skin involvement in patients affected by limited cutaneous systemic sclerosis (lcSSc), in those skin areas apparen...

    A. Sulli, B. Ruaro, V. Smith, S. Paolino, C. Pizzorni, G. Pesce and M. Cutolo

    Arthritis Research & Therapy 2017 19:61

    Published on: 20 March 2017

  6. Research article

    Increased serum levels of fractalkine and mobilisation of CD34+CD45 endothelial progenitor cells in systemic sclerosis

    The disruption of endothelial homeostasis is a major determinant in the pathogenesis of systemic sclerosis (SSc) and is reflected by soluble and cellular markers of activation, injury and repair. We aimed to p...

    Audrey Benyamine, Jérémy Magalon, Sylvie Cointe, Romaric Lacroix, Laurent Arnaud, Nathalie Bardin, Pascal Rossi, Yves Francès, Fanny Bernard-Guervilly, Gilles Kaplanski, Jean-Robert Harlé, Pierre-Jean Weiller, Philippe Berbis, David Braunstein, Elisabeth Jouve, Nathalie Lesavre…

    Arthritis Research & Therapy 2017 19:60

    Published on: 20 March 2017

  7. Research article

    Association of the lupus low disease activity state (LLDAS) with health-related quality of life in a multinational prospective study

    Systemic lupus erythematosus (SLE) is associated with significant impairment of health-related quality of life (HR-QoL). Recently, meeting a definition of a lupus low disease activity state (LLDAS), analogous ...

    Vera Golder, Rangi Kandane-Rathnayake, Alberta Yik-Bun Hoi, Molla Huq, Worawit Louthrenoo, Yuan An, Zhan Guo Li, Shue Fen Luo, Sargunan Sockalingam, Chak Sing Lau, Mo Yin Mok, Aisha Lateef, Kate Franklyn, Susan Morton, Sandra Teresa V. Navarra, Leonid Zamora…

    Arthritis Research & Therapy 2017 19:62

    Published on: 20 March 2017

  8. Research article

    Accuracy of magnetic resonance imaging to detect cartilage loss in severe osteoarthritis of the first carpometacarpal joint: comparison with histological evaluation

    Magnetic resonance imaging (MRI) is increasingly used for research in hand osteoarthritis, but imaging the thin cartilage layers in the hand joints remains challenging. We therefore assessed the accuracy of MR...

    Michael S. Saltzherr, J. Henk Coert, Ruud W. Selles, Johan W. van Neck, Jean-Bart Jaquet, Gerjo J. V. M. van Osch, Edwin H. G. Oei, Jolanda J. Luime and Galied S. R. Muradin

    Arthritis Research & Therapy 2017 19:55

    Published on: 14 March 2017

  9. Research article

    Chromatin landscapes and genetic risk for juvenile idiopathic arthritis

    The transcriptomes of peripheral blood cells in children with juvenile idiopathic arthritis (JIA) have distinct transcriptional aberrations that suggest impairment of transcriptional regulation. To gain a bett...

    Lisha Zhu, Kaiyu Jiang, Karstin Webber, Laiping Wong, Tao Liu, Yanmin Chen and James N. Jarvis

    Arthritis Research & Therapy 2017 19:57

    Published on: 14 March 2017

  10. Research article

    Activation status of mucosal-associated invariant T cells reflects disease activity and pathology of systemic lupus erythematosus

    Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes constituting a large proportion of peripheral blood T cells expressing αβ T-cell receptor in humans. In this study, we aimed to investiga...

    Asako Chiba, Naoto Tamura, Kazunori Yoshikiyo, Goh Murayama, Mie Kitagaichi, Ken Yamaji, Yoshinari Takasaki and Sachiko Miyake

    Arthritis Research & Therapy 2017 19:58

    Published on: 14 March 2017

  11. Research article

    Low disease activity for up to 3 years after adalimumab discontinuation in patients with early rheumatoid arthritis: 2-year results of the HOPEFUL-3 Study

    This study was conducted to evaluate the feasibility of long-term adalimumab (ADA) discontinuation after achievement of low disease activity (LDA) in Japanese patients with early rheumatoid arthritis (RA) and ...

    Yoshiya Tanaka, Hisashi Yamanaka, Naoki Ishiguro, Nobuyuki Miyasaka, Katsuyoshi Kawana, Junko Kimura, Naoki Agata and Tsutomu Takeuchi

    Arthritis Research & Therapy 2017 19:56

    Published on: 14 March 2017

  12. Research article

    Support for phosphoinositol 3 kinase and mTOR inhibitors as treatment for lupus using in-silico drug-repurposing analysis

    Systemic lupus erythematosus (SLE) is an autoimmune disease with few treatment options. Current therapies are not fully effective and show highly variable responses. In this regard, large efforts have focused ...

    Daniel Toro-Domínguez, Pedro Carmona-Sáez and Marta E. Alarcón-Riquelme

    Arthritis Research & Therapy 2017 19:54

    Published on: 11 March 2017

  13. Research article

    Phase 1b randomized, double-blind study of namilumab, an anti-granulocyte macrophage colony-stimulating factor monoclonal antibody, in mild-to-moderate rheumatoid arthritis

    Namilumab (AMG203) is an immunoglobulin G1 monoclonal antibody that binds with high affinity to the GM-CSF ligand. This was a phase 1b, randomized, double-blind study (PRIORA) to assess namilumab in active, mi...

    T. W. J. Huizinga, A. Batalov, R. Stoilov, E. Lloyd, T. Wagner, D. Saurigny, B. Souberbielle and E. Esfandiari

    Arthritis Research & Therapy 2017 19:53

    Published on: 9 March 2017

  14. Research article

    Elevated serum autoantibodies against co-inhibitory PD-1 facilitate T cell proliferation and correlate with disease activity in new-onset systemic lupus erythematosus patients

    Programmed cell death protein 1 (PD-1) plays an important role in immune response regulation as a co-inhibitory signal during T cell activation. However, there is little known about the serum autoantibody prof...

    Hui Shi, Junna Ye, Jialin Teng, Yufeng Yin, Qiongyi Hu, Xinyao Wu, Honglei Liu, Xiaobing Cheng, Yutong Su, Mengru Liu, Juanfang Gu, Ting Lu, HaoJie Chen, Hui Zheng, Yue Sun and Chengde Yang

    Arthritis Research & Therapy 2017 19:52

    Published on: 9 March 2017

  15. Research article

    Characterization of the HLA-DRβ1 third hypervariable region amino acid sequence according to charge and parental inheritance in systemic sclerosis

    Specific HLA class II alleles are associated with systemic sclerosis (SSc) risk, clinical characteristics, and autoantibodies. HLA nomenclature initially developed with antibodies as typing reagents defining D...

    Coline A. Gentil, Hilary S. Gammill, Christine T. Luu, Maureen D. Mayes, Dan E. Furst and J. Lee Nelson

    Arthritis Research & Therapy 2017 19:46

    Published on: 7 March 2017

  16. Commentary

    Rheumatology in Africa—challenges and opportunities

    Africa faces many health challenges despite sustained growth and development over the past decade. Contributory factors are the lack of financial resources, an inadequate health professional workforce, a high ...

    Girish M. Mody

    Arthritis Research & Therapy 2017 19:49

    Published on: 7 March 2017

  17. Research article

    Social media for arthritis-related comparative effectiveness and safety research and the impact of direct-to-consumer advertising

    Social media may complement traditional data sources to answer comparative effectiveness/safety questions after medication licensure.

    Jeffrey R. Curtis, Lang Chen, Phillip Higginbotham, W. Benjamin Nowell, Ronit Gal-Levy, James Willig, Monika Safford, Joseph Coe, Kaitlin O’Hara and Roee Sa’adon

    Arthritis Research & Therapy 2017 19:48

    Published on: 7 March 2017

  18. Research article

    Multiplex serum protein analysis reveals potential mechanisms and markers of response to hyperimmune caprine serum in systemic sclerosis

    Hyperimmune caprine serum (HICS) is a novel biological therapy with potential benefit for skin in established diffuse cutaneous systemic sclerosis. Here we report multiplex protein analysis of blood samples fr...

    Niamh Quillinan, Kristina E. N. Clark, Bryan Youl, Jeffrey Vernes, Deirdre McIntosh, Syed Haq and Christopher P. Denton

    Arthritis Research & Therapy 2017 19:45

    Published on: 7 March 2017

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