Fig. 2
From: Targeting an inflammation-amplifying cell population can attenuate osteoarthritis-associated pain
Modulation of Inf A through a Jnk inhibitor (Jnki) in the tibia loading model for PTOA. A Schematic showing strategy for Jnk inhibitor administration starting 1 week post-tibia loading. B Sagittal sections of knee joint showing cartilage degradation at 10 weeks upon tibia loading. C Sagittal sections showing inflamed synovium in the knee cartilage in the tibia-loaded mice. D, E OARSI scores for knee cartilage at 10 weeks post-tibia loading (n = 7). F Hyperplasia score for synovium lining in the tibia-loaded mice (Uninjured (n = 5), Vehicle (n = 5), Jnki (n = 6)). Significance was calculated using Student’s t test with Welch’s correction. *p < 0.05, **p < 0.01, ***p < 0.001