Fig. 3
From: Targeting an inflammation-amplifying cell population can attenuate osteoarthritis-associated pain
Jnk inhibition attenuates Inflammatory cytokines and improves gait in mice. A Heatmap showing levels of inflammatory cytokines in the serum of mice that received vehicle control or Jnki (n = 3, each group). B, C Levels of cytokines CCL2 and CCL7 upon Jnki administration in tibia-loaded mice as measured by mean fluorescence intensity (MFI) average; significance calculated using Student’s t test with Welch’s correction. D Schematic depicting the strategy for gait analysis of tibia-loaded mice upon Jnki administration. Changes in the gait parameters upon tibia loading and Jnki administration in mice. E MaxContactAt (%), F mean intensity (arbitrary units), and G step cycle (s) (S n (sham) = 6, n (Veh) = 6, n (Jnki) = 7), significance calculated using one way ANOVA with Tukey’s multiple comparison. *p < 0.05, **p < 0.01 (individual adjusted p values: mean intensity (Sham vs. Veh, 0.0024, Sham vs. Jnk2i, 0.9057, Veh vs. Jnk2i, 0.0042), MaxContactAt (Sham vs. Veh, 0.0446, Sham vs. Jnk2i, 0.9999, Veh vs. Jnk2i, 0.0371), step cycle (Sham vs. Veh, 0.0393, Sham vs. Jnk2i, 0.8104, Veh vs. Jnk2i, 0.0091)