Fig. 4

Intra-articular JNK inhibition does not lead to any increase in p16⁺ senescent cells. A Knee joint sagittal sections stained with p16 antibody upon 10 weeks post-tibia loading (vehicle—above, Jnki—below) showing expression of p16 in synovium, cartilage, and meniscus along with a higher magnification. B Quantification of p16-positive cells in synovium, cartilage, and meniscus of the tibia-loaded mice. Statistical analysis was performed using Student’s t test with Welch’s correction. Scale bar = 300 μm