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  1. Serum exosomes play important roles in intercellular communication and are promising biomarkers of several autoimmune diseases. However, the biological functions and potential clinical importance of long non-c...

    Authors: Li Xue, Biao Wang, Xueyi Li, Jianhong Zhu, Wei Wang, Fang Huang, Xiaofei Wang, Yaofeng Jin, Chaoliang Xiong, Li Tao, Ke Xu, Jing Wang, Ying Guo, Jing Xu, Xin Yang, Na Wang…
    Citation: Arthritis Research & Therapy 2023 25:201
  2. In systemic lupus erythematosus (SLE), autoreactive B cells are thought to develop by-passing immune checkpoints and contribute to its pathogenesis. Toll-like receptor (TLR) 7 and 9 signaling have been implica...

    Authors: Ken Yasaka, Tomohide Yamazaki, Hiroko Sato, Tsuyoshi Shirai, Minkwon Cho, Koji Ishida, Koyu Ito, Tetsuhiro Tanaka, Kouetsu Ogasawara, Hideo Harigae, Tomonori Ishii and Hiroshi Fujii
    Citation: Arthritis Research & Therapy 2023 25:200
  3. Giant cell arteritis (GCA) is primarily treated with glucocorticoids (GCs), which have substantial toxicity. Tocilizumab, an interleukin-6-receptor inhibitor (IL-6Ri), showed beneficial effects in GCA, leading...

    Authors: Wolfgang A. Schmidt, Bhaskar Dasgupta, Jennifer Sloane, Angeliki Giannelou, Yuqing Xu, Sebastian H. Unizony, Sarah L. Mackie, Miguel A. Gonzalez-Gay, Robert Spiera, Kenneth J. Warrington, Peter M. Villiger, Michael C. Nivens, Bolanle Akinlade, Yong Lin, Frank Buttgereit and John H. Stone
    Citation: Arthritis Research & Therapy 2023 25:199
  4. The clinical value of 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in assessing relapsing polychondritis (RP) with airway involvement remains controversial. This study ai...

    Authors: Jing-Wei Yi, Jun-Feng Huang, Peng Hou, Zi-Kai Lin, Jin-Sheng Lin, Si-Yan Lin, Min Wang, Shi-Yue Li and Xin-Lu Wang
    Citation: Arthritis Research & Therapy 2023 25:198
  5. Cellular senescence is a critical factor contributing to osteoarthritis (OA). Overexpression of chromobox homolog 4 (CBX4) in a mouse system was demonstrated to alleviate post-traumatic osteoarthritis (PTOA) b...

    Authors: Yu-Hsiu Chen, Xin Zhang, David Attarian and Virginia Byers Kraus
    Citation: Arthritis Research & Therapy 2023 25:197
  6. Upadacitinib (UPA) is a selective JAK inhibitor recently approved for the treatment of psoriatic arthritis (PsA). In this post-approval study, we aimed to evaluate the effectiveness and safety of UPA over 24 w...

    Authors: Michele Maria Luchetti Gentiloni, Valentino Paci, Antonio Carletto, Alen Zabotti, Roberta Ramonda, Maria Sole Chimenti, Lorenzo Dagna, Nicoletta Luciano, Anna Piccinelli, Ivan Giovannini, Giovanni Striani, Nicola Boffini, Gilda Sandri, Niccolò Possemato, Ilenia Pantano, Devis Benfaremo…
    Citation: Arthritis Research & Therapy 2023 25:196
  7. β2-glycoprotein I (β2GPI) complexed with human leukocyte antigen DR (β2GPI/HLA-DR) was found to be a major autoantibody target in antiphospholipid syndrome (APS). This study aimed to reveal the association bet...

    Authors: Katsuhiko Yoneda, Yo Ueda, Kenji Tanimura, Hisashi Arase, Hideto Yamada and Jun Saegusa
    Citation: Arthritis Research & Therapy 2023 25:195
  8. Ankylosing spondylitis (AS) is a chronic inflammatory disease that mainly affects the sacroiliac joint and spine. However, the real mechanisms of immune cells acting on syndesmophyte formation in AS are not we...

    Authors: Yulong Tang, Kai Yang, Qingmei Liu, Yanyun Ma, Hao Zhu, Kunhai Tang, Chengchun Geng, Jiangnan Xie, Dachun Zhuo, Wenyu Wu, Li Jin, Wenze Xiao, Jiucun Wang, Qi Zhu and Jing Liu
    Citation: Arthritis Research & Therapy 2023 25:194
  9. Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised by joint pain and swelling, synovial hyperplasia, cartilage damage, and bone destruction. The mechanisms of dendritic cell (DC) and T c...

    Authors: Zhandong Wang, Jinlong Zhang, Fangyu An, Jie Zhang, Xiangrui Meng, Shiqing Liu, Ruoliu Xia, Gang Wang and Chunlu Yan
    Citation: Arthritis Research & Therapy 2023 25:193
  10. Autoantibodies are critical elements in RA pathogenesis and clinical assessment. The anti-malondialdehyde-acetaldehyde (anti-MAA) antibodies are potentially useful because of their claimed high sensitivity for...

    Authors: Lorena Rodriguez-Martinez, Cristina García-Moreno, Eva Perez-Pampin, María J. Gómara, Juan C. Sarmiento-Monroy, Yolanda Lopez-Golán, José A. Gómez-Puerta, Antonio Mera-Varela, Carmen Conde, Raimon Sanmartí, Isabel Haro and Antonio González
    Citation: Arthritis Research & Therapy 2023 25:192
  11. While many women with rheumatoid arthritis (RA) improve during pregnancy and others worsen, there are no biomarkers to predict this improvement or worsening. In our unique RA pregnancy cohort that includes a p...

    Authors: Matthew Wright, Mette Kiel Smed, J. Lee Nelson, Jørn Olsen, Merete Lund Hetland, Nicholas P. Jewell, Vibeke Zoffmann and Damini Jawaheer
    Citation: Arthritis Research & Therapy 2023 25:191
  12. As current therapies for canine osteoarthritis (OA) provide mainly symptomatic improvement and fail to address the complex pathology of the disease, mesenchymal stem cells (MSCs) offer a promising biological a...

    Authors: Charlotte Beerts, Sarah Y. Broeckx, Eva Depuydt, Liesa Tack, Lore Van Hecke, Koen Chiers, Leen Van Brantegem, Gabriele Braun, Klaus Hellmann, Nathalie de Bouvre, Nathalie Van Bruaene, Tine De Ryck, Luc Duchateau, Bernadette Van Ryssen, Kathelijne Peremans, Jimmy H. Saunders…
    Citation: Arthritis Research & Therapy 2023 25:190
  13. N6-methyladenosine (m6A) methylation modification is involved in the regulation of various biological processes, including inflammation, antitumor, and antiviral immunity. However, the role of m6A modification...

    Authors: Yurong Huang, Qiuyun Xue, Jun Chang, Yuting Wang, Chenglong Cheng, Suowen Xu, Xiao Wang and Chenggui Miao
    Citation: Arthritis Research & Therapy 2023 25:189
  14. To examine and quantify liver and kidney lesions and their response to anti-tumor necrosis factor (TNF) therapy in a TNF-Tg mouse model of rheumatoid arthritis (RA).

    Authors: Xuefei Li, Yi Wang, Ziqiang Chen, Ming Ruan, Can Yang, Maolin Zhou, Ning Li, Lianping Xing, Hao Xu, Ling Yang, Qi Shi, Yongjun Wang, Jinman Chen and Qianqian Liang
    Citation: Arthritis Research & Therapy 2023 25:188
  15. Primary biliary cholangitis (PBC) is an autoimmune liver disease, whose etiology is yet to be fully elucidated. Currently, ursodeoxycholic acid (UDCA) is the only first-line drug. However, 40% of PBC patients ...

    Authors: Siyuan Tian, Yinan Hu, Miao Zhang, Kemei Wang, Guanya Guo, Bo Li, Yulong Shang and Ying Han
    Citation: Arthritis Research & Therapy 2023 25:186
  16. Rheumatoid arthritis (RA) has a variable impact on different synovial joints, with inflammation being more commonly observed in some joints than others. Emerging evidence suggests that the anatomical variation...

    Authors: Adrian Ciurea, Oliver Distler, Kenneth Kwok, Hyejin Jo, Lisy Wang, Tim Killeen, Caroline Ospelt and Mojca Frank Bertoncelj
    Citation: Arthritis Research & Therapy 2023 25:185
  17. Studies evaluating the association of knee and hip osteoarthritis (OA) with falls and fractures have inconsistent findings. We aimed to investigate associations of symptomatic and radiographic knee and hip OA ...

    Authors: Youyou Zhang, Xiaoxi Li, Yining Wang, Liru Ge, Faming Pan, Tania Winzenberg and Guoqi Cai
    Citation: Arthritis Research & Therapy 2023 25:184
  18. To compare a treat-to-target (T2T) approach and routine care (RC) in adults with active to severely active rheumatoid arthritis (RA) initiating subcutaneous abatacept.

    Authors: Louis Bessette, Boulos Haraoui, Emmanouil Rampakakis, Joanna Dembowy, Marc-Olivier Trépanier and Janet Pope
    Citation: Arthritis Research & Therapy 2023 25:183
  19. Physical function is an important determinant of health-related quality of life in radiographic axial spondyloarthritis patients (r-axSpA). To improve the basis of effective healthcare efforts, we aimed to inv...

    Authors: Magnus Hallström, Eva Klingberg, Anna Deminger, Jeannette Beckman Rehnman, Mats Geijer and Helena Forsblad-d’Elia
    Citation: Arthritis Research & Therapy 2023 25:182
  20. This work aims to develop a deep learning model, assessing atlantoaxial subluxation (AAS) in rheumatoid arthritis (RA), which can often be ambiguous in clinical practice.

    Authors: Yasutaka Okita, Toru Hirano, Bowen Wang, Yuta Nakashima, Saki Minoda, Hajime Nagahara and Atsushi Kumanogoh
    Citation: Arthritis Research & Therapy 2023 25:181
  21. Dimerization of the myeloid differentiation primary response 88 protein (MyD88) plays a pivotal role in the exacerbated response to innate immunity-dependent signaling in rheumatoid arthritis (RA). ST2825 is a...

    Authors: Sergio Ramirez-Perez, Rushi Vekariya, Surabhi Gautam, Itzel Viridiana Reyes-Perez, Hicham Drissi and Pallavi Bhattaram
    Citation: Arthritis Research & Therapy 2023 25:180
  22. Osteoarthritis (OA) is a common degenerative joint disease and causes chronic pain and disability to the elderly. Several risk factors are involved, such as aging, obesity, genetic susceptibility, and environm...

    Authors: Lin Mei, Zhiming Zhang, Ruiqi Chen, Zhongyue Liu, Xiaolei Ren and Zhihong Li
    Citation: Arthritis Research & Therapy 2023 25:179
  23. This study aimed to investigate the long-term effect of vitamin D supplementation compared to placebo over 5 years in participants with knee osteoarthritis (OA). We also aimed to describe the effect of maintai...

    Authors: Zhiqiang Wang, Zhaohua Zhu, Feng Pan, Shuang Zheng, Venkat Parameswaran, Leigh Blizzard, Changhai Ding and Benny Antony
    Citation: Arthritis Research & Therapy 2023 25:178
  24. Juvenile idiopathic arthritis (JIA) treatment is aimed at inducing remission to prevent joint destruction and disability. However, it is unclear what is the long-term impact on health-related outcomes of the t...

    Authors: Filipa Oliveira Ramos, Ana Maria Rodrigues, Ana Teresa Melo, Francisca Aguiar, Luísa Brites, Soraia Azevedo, Ana Catarina Duarte, José António Melo Gomes, Carolina Furtado, Ana Filipa Mourão, Graça Sequeira, Inês Cunha, Ricardo Figueira, Maria José Santos and João Eurico Fonseca
    Citation: Arthritis Research & Therapy 2023 25:177
  25. Synovial fibroblasts in rheumatoid arthritis (RAFLS) exhibit a pathological aberration of glycolysis and glutaminolysis. Henceforth, we aimed to investigate if dual inhibition of these pathways by phytobiologi...

    Authors: Shanzay Ahmed, Christopher B. Mahony, Alyssa Torres, Jessica Murillo-Saich, Samuel Kemble, Martha Cedeno, Peter John, Attya Bhatti, Adam P. Croft and Monica Guma
    Citation: Arthritis Research & Therapy 2023 25:176
  26. Pulmonary arterial hypertension (PAH) is a rare complication of primary Sjögren’s syndrome (pSS). Several genes have proven to be associated with pSS and PAH. However, there is no study specifically addressing...

    Authors: Mucong Li, Yue Shi, Jiuliang Zhao, Qian Wang, Mengtao Li and Xiuli Zhao
    Citation: Arthritis Research & Therapy 2023 25:175
  27. While the availability of biological or targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs) has improved outcomes for rheumatoid arthritis (RA) patients, there remains a subset of individual...

    Authors: Ju-Yang Jung, Eunyoung Lee, Ji-Won Kim, Chang-Hee Suh, Kichul Shin, Jinhyun Kim and Hyoun-Ah Kim
    Citation: Arthritis Research & Therapy 2023 25:174
  28. Osteoarthritis (OA) is driven by low-grade inflammation, and controlling local inflammation may offer symptomatic relief. Here, we developed an indoleamine 2,3-dioxygenase and galectin-3 fusion protein (IDO-Ga...

    Authors: Brittany D. Partain, Evelyn Bracho-Sanchez, Shaheen A. Farhadi, Elena G. Yarmola, Benjamin G. Keselowsky, Gregory A. Hudalla and Kyle D. Allen
    Citation: Arthritis Research & Therapy 2023 25:173
  29. Upadacitinib, a Janus kinase inhibitor, has demonstrated efficacy and an acceptable safety profile in patients with ankylosing spondylitis (AS) in the phase III SELECT-AXIS programs. We report the 1-year effic...

    Authors: Xenofon Baraliakos, Désirée van der Heijde, Joachim Sieper, Robert D. Inman, Hideto Kameda, Yihan Li, Xianwei Bu, Anna Shmagel, Peter Wung, In-Ho Song and Atul Deodhar
    Citation: Arthritis Research & Therapy 2023 25:172
  30. Several observational studies have explored the associations between Sjögren’s syndrome (SS) and certain cancers. Nevertheless, the causal relationships remain unclear. Mendelian randomization (MR) method was ...

    Authors: Yiwei Jia, Peizhuo Yao, Jia Li, Xinyu Wei, Xuanyu Liu, Huizi Wu, Weiwei Wang, Cong Feng, Chaofan Li, Yu Zhang, Yifan Cai, Shuqun Zhang and Xingcong Ma
    Citation: Arthritis Research & Therapy 2023 25:171
  31. Authors: Georg Schett, Warner Chen, Sheng Gao, Soumya D. Chakravarty, May Shawi, Frederic Lavie, Miriam Zimmermann, Mohamed Sharaf, Laura C. Coates and Stefan Siebert
    Citation: Arthritis Research & Therapy 2023 25:170

    The original article was published in Arthritis Research & Therapy 2023 25:150

  32. Nail psoriasis is a common, physiologically, and psychologically disruptive, and yet often under-treated manifestation of psoriasis. The objectives of this analysis were to investigate the trajectory of nail p...

    Authors: William Tillett, Alexander Egeberg, Enikö Sonkoly, Patricia Gorecki, Anna Tjärnlund, Jozefien Buyze, Sven Wegner and Dennis McGonagle
    Citation: Arthritis Research & Therapy 2023 25:169
  33. Osteoarthritis (OA) is a degenerative joint disease associated with aging, which often leads to joint stiffness and disability. Exercise is one of the most important non-pharmacological treatments and is presc...

    Authors: Kosuke Norimatsu, Kazuki Nakanishi, Toshiro Ijuin, Shotaro Otsuka, Seiya Takada, Akira Tani, Ryoma Matsuzaki, Teruki Matsuoka and Harutoshi Sakakima
    Citation: Arthritis Research & Therapy 2023 25:168
  34. Uncontrolled T-cell activation plays a key role in systemic sclerosis (SSc). Arsenic trioxide (ATO) has immunological effects and has demonstrated potential in preclinical SSc models. In this study, we assesse...

    Authors: Anne Cauvet, Arthur Decellas, Christophe Guignabert, Dominique Rongvaux-Gaïda, Raphaël Thuillet, Mina Ottaviani, Ly Tu, François Rieger, Jérôme Avouac and Yannick Allanore
    Citation: Arthritis Research & Therapy 2023 25:167
  35. Real-world studies assessing the comparative effectiveness of biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) as first-line targeted therapy are scarce. We analyzed the real-w...

    Authors: Dimitrios A. Pappas, Jacqueline O’Brien, Lin Guo, Ying Shan, Joshua F. Baker, Gregory Kricorian, Scott Stryker and David H. Collier
    Citation: Arthritis Research & Therapy 2023 25:166
  36. Neuropsychiatric systemic lupus erythematosus (NPSLE), with various morbidities and multiple manifestations in the central nervous system, remains a limited standard for diagnosis. Our study was to discover no...

    Authors: Jiali Ni, Chen Chen, Shuangan Wang, Xuan Liu, Liping Tan, Li Lu, Yu Fan, Yayi Hou, Huan Dou and Jun Liang
    Citation: Arthritis Research & Therapy 2023 25:165
  37. Low urine pH, which may be mediated by metabolic syndrome (MetS), is common in gout. Tart cherries are shown to improve MetS symptoms and possess anti-inflammatory properties. However, the efficacy of tart che...

    Authors: Can Wang, Wenyan Sun, Nicola Dalbeth, Zhongjun Wang, Xuefeng Wang, Xiaopeng Ji, Xiaomei Xue, Lin Han, Lingling Cui, Xinde Li, Zhen Liu, Aichang Ji, Yuwei He, Mingshu Sun and Changgui Li
    Citation: Arthritis Research & Therapy 2023 25:164
  38. We investigated sensitivity of the 2020 Revised Comprehensive Diagnostic Criteria (RCD) and the 2019 ACR/EULAR classification criteria across the four identified IgG4-related disease (IgG4-RD) phenotypes: “Pan...

    Authors: Jens Vikse, Øyvind Midtvedt, Bjørg-Tilde Svanes Fevang, Torhild Garen, Øyvind Palm, Marianne Wallenius, Gunnstein Bakland, Katrine Brække Norheim, Øyvind Molberg and Anna-Maria Hoffmann-Vold
    Citation: Arthritis Research & Therapy 2023 25:163
  39. Interstitial lung disease (ILD) is the most common cause of death in patients with systemic sclerosis (SSc). Prognostic biomarkers are needed to identify SSc-ILD patients at risk for progressive pulmonary fibr...

    Authors: Viggo Hamberg, Azita Sohrabian, Elizabeth R. Volkmann, Marie Wildt, Anna Löfdahl, Dirk M. Wuttge, Roger Hesselstrand, Göran Dellgren, Gunilla Westergren-Thorsson, Johan Rönnelid and Kristofer Andréasson
    Citation: Arthritis Research & Therapy 2023 25:162
  40. Curcumin, a component of the South-Asian spice turmeric, elicits anti-inflammatory functions. We have previously demonstrated that a highly bioavailable formulation of cucurmin, Cureit/Acuminâ„¢ (CUR), can suppr...

    Authors: Mahadevappa Hemshekhar, Dylan Lloyd, Hani El-Gabalawy and Neeloffer Mookherjee
    Citation: Arthritis Research & Therapy 2023 25:161
  41. Authors: Mumina Akthar, Nisha Nair, Lucy M. Carter, Edward M. Vital, Emily Sutton, Neil McHugh, Ian N. Bruce and John A. Reynolds
    Citation: Arthritis Research & Therapy 2023 25:160

    The original article was published in Arthritis Research & Therapy 2023 25:111

  42. Rheumatoid arthritis (RA) is a chronic, systemic, autoimmune disease of unknown etiology with erosive, symmetric polyarthritis as the main clinical manifestations. Its basic pathological changes are the format...

    Authors: Yubo Shao, Hong Zhang, Qi Shi, Yongjun Wang and Qianqian Liang
    Citation: Arthritis Research & Therapy 2023 25:159
  43. Rheumatoid arthritis (RA) is one of the most prevalent and debilitating joint diseases worldwide. RA is characterized by synovial inflammation (synovitis), which is linked to the development of joint destructi...

    Authors: Wessel F. Theeuwes, Irene Di Ceglie, Daphne N. Dorst, Arjen B. Blom, Desiree L. Bos, Thomas Vogl, Sander W. Tas, Pilar Jimenez-Royo, Mats Bergstrom, Matthew Cleveland, Peter M. van der Kraan, Peter Laverman, Marije I. Koenders, Peter L. van Lent and Martijn H. J. van den Bosch
    Citation: Arthritis Research & Therapy 2023 25:158
  44. To investigate if extracellular matrix (ECM) blood-based biomarkers reflect the pharmacodynamic effect and response to TNF-α inhibitor therapy (adalimumab, ADA), in patients with axial spondyloarthritis (axSpA).

    Authors: Helena Port, Signe Holm Nielsen, Peder Frederiksen, Sofie Falkenløve Madsen, Anne-Christine Bay-Jensen, Inge Juul Sørensen, Bente Jensen, Anne Gitte Loft, Ole Rintek Madsen, Mikkel Østergaard and Susanne Juhl Pedersen
    Citation: Arthritis Research & Therapy 2023 25:157
  45. Systemic sclerosis (SSc) is a connective tissue disease that is characterized by fibrosis in the skin and internal organs, such as the lungs. Activated differentiation of progenitor cells, which are mainly res...

    Authors: Hiroshi Kasamatsu, Takenao Chino, Takumi Hasegawa, Natsuko Utsunomiya, Akira Utsunomiya, Masami Yamada, Noritaka Oyama and Minoru Hasegawa
    Citation: Arthritis Research & Therapy 2023 25:156
  46. Pulmonary arterial hypertension (PAH) is a severe complication of systemic lupus erythematosus (SLE). This study aims to explore the clinical characteristics and prognosis in SLE-PAH based on consensus cluster...

    Authors: Mengmeng Dai, Chunyi Zhang, Chaoying Li, Qianqian Wang, Congcong Gao, Runzhi Yue, Menghui Yao, Zhaohui Su and Zhaohui Zheng
    Citation: Arthritis Research & Therapy 2023 25:155
  47. Osteoarthritis (OA) is increasingly recognised as a whole joint disease, with an important role for synovium. However, the repertoire of immune cells and fibroblasts that constitute OA synovium remains underst...

    Authors: Jolet Y. Mimpen, Robert Hedley, Anna Ridley, Mathew J. Baldwin, Dylan Windell, Ananya Bhalla, Lorenzo Ramos-Mucci, Christopher D. Buckley, Mark C. Coles, Abtin Alvand, Andrew J. Price, Andrew J. Carr, Stephanie G. Dakin and Sarah J. B. Snelling
    Citation: Arthritis Research & Therapy 2023 25:154
  48. Tofacitinib is an oral Janus kinase inhibitor for the treatment of psoriatic arthritis (PsA). This post hoc analysis assessed tofacitinib efficacy on enthesitis by baseline location and severity, and impact on...

    Authors: Philip J. Mease, Ana-Maria Orbai, Oliver FitzGerald, Mohamed Bedaiwi, Dona L. Fleishaker, Rajiv Mundayat, Pamela Young and Philip S. Helliwell
    Citation: Arthritis Research & Therapy 2023 25:153
  49. Iguratimod (IGU) reduces hypergammaglobulinemia and disease activity in pSS (primary Sjögren’s syndrome) patients. However, the therapeutical mechanism of IGU for pSS remains largely unknown. This study aimed ...

    Authors: Taibiao Lyu, Hui Jiang, Liuting Zeng, Suying Liu, Chengmei He, Chaowen Luo, Lin Qiao, Yan Zhao and Hua Chen
    Citation: Arthritis Research & Therapy 2023 25:152

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