HLA class II associations with rheumatic heart disease among clinically homogeneous patients in children in Latvia

Table 3 Frequencies of DRB1 and DQB1 alleles in RF and RHD patients compared with control subjects

Group (n = 140)		DRB1*06	DRB1*07	DQB1*0302	DQB1*0401-2
All RF (n = 140)	gf(P) + OR/χ²	(0.0023) 0.18/11.96	(0.01) 4.18/6.68	(0.001) 3.13/10.67	(0.015) 4.33/11.79
MVR (n = 48)	gf(P) + OR/χ²	0.15	(0.03) 4.45/4.95	1.09	(0.001) 8.20/21.59
MVL (n = 40)	gf(P) + OR/χ²	0.18	(0.01) 5.44/6.59	(0.001) 4.18/10.21	1.25
Sydenham's chorea (n = 16)	gf(P) + OR/χ²	0	(0.002)11.31/13.19	1.79	(0.005) 6.36/7.17
without RHD (n = 46)	gf(P) + OR/χ²	0.31	(0.001) 7.35/11.65	(0.005) 3.50/7.81	(0.01) 4.14/6.78
Control subjects (n = 200)	gf	0.14	0.02	0.07	0.04

Boldface type highlights statistically significant associations for patients vs controls. gf (gene frequency) P (probability), OR (odds ratio), and Mantel-Hanszel values (χ²) are reported only for significant associations (P < 0.05). n = number of haplotypes (e.g. 140 haplotypes from 70 individuals). The nature of valve lesions was not reported for two patients. MVL, multivalvular lesions; MVR, mitral valve regurgitation; RF, rheumatic fever; RHD, rheumatic heart disease.

ISSN: 1478-6362