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Table 3 Frequencies of DRB1 and DQB1 alleles in RF and RHD patients compared with control subjects

From: HLA class II associations with rheumatic heart disease among clinically homogeneous patients in children in Latvia

Group (n = 140)   DRB1*06 DRB1*07 DQB1*0302 DQB1*0401-2
All RF (n = 140) gf(P) + OR/χ2 (0.0023) 0.18/11.96 (0.01) 4.18/6.68 (0.001) 3.13/10.67 (0.015) 4.33/11.79
MVR (n = 48) gf(P) + OR/χ2 0.15 (0.03) 4.45/4.95 1.09 (0.001) 8.20/21.59
MVL (n = 40) gf(P) + OR/χ2 0.18 (0.01) 5.44/6.59 (0.001) 4.18/10.21 1.25
Sydenham's chorea (n = 16) gf(P) + OR/χ2 0 (0.002)11.31/13.19 1.79 (0.005) 6.36/7.17
without RHD (n = 46) gf(P) + OR/χ2 0.31 (0.001) 7.35/11.65 (0.005) 3.50/7.81 (0.01) 4.14/6.78
Control subjects (n = 200) gf 0.14 0.02 0.07 0.04
  1. Boldface type highlights statistically significant associations for patients vs controls. gf (gene frequency) P (probability), OR (odds ratio), and Mantel-Hanszel values (χ2) are reported only for significant associations (P < 0.05). n = number of haplotypes (e.g. 140 haplotypes from 70 individuals). The nature of valve lesions was not reported for two patients. MVL, multivalvular lesions; MVR, mitral valve regurgitation; RF, rheumatic fever; RHD, rheumatic heart disease.