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Figure 1 | Arthritis Res Ther

Figure 1

From: Electrophoretic characterization of species of fibronectin bearing sequences from the N-terminal heparin-binding domain in synovial fluid samples from patients with osteoarthritis and rheumatoid arthritis

Figure 1

Structure of fibronectin (FN), including recognition sites for the monoclonal anti-FN antibodies used in this study. The structure of an intact FN subunit is shown, with the approximate binding sites for the three anti-FN monoclonal antibodies used in this study denoted by brackets at the top and binding specificities for various domains and structural motifs shown at the bottom. The primary FN sequence extends from the amino (N) terminus (NH2, left) to the carboxy (C) terminus (COOH, right) and consists of repeating motifs designated type I, II, and III repeats. In addition to the 10th (counting rightward from the N terminus) type III repeat, cell surface integrin-binding motifs ('Cell') have been localized to the alternatively spliced EIIIA and V segments. The cysteine residues through which subunits are dimerized are depicted near the C terminus.

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