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Table 2 Adverse events reported during the first and second rituximab or placebo infusions in patients with rheumatoid arthritis

From: Safety of rituximab in the treatment of B cell malignancies: implications for rheumatoid arthritis

  First infusion Second infusion
Adverse event Placebo Rituximab (1000 mg) Placebo Rituximab (1000 mg)
Any adverse event 30 36 15 17
Transient hypotension 20 13 10 12
Transient hypertension 10 9 5 3
Flushing - 4 - 1
Pruritus - 6 - -
Rash - 4 - -
Dyspnoea - 3 - -
Pharynx discomfort - 3 - -
Pyrexia - 3 - -
Headache - 2 - -
  1. Hypotension/hypertension were defined as an increase/decrease in systolic or diastolic pressure of more than 30 mmHg. Values are expressed as percentages. Data from Szczepański and coworkers [23].