Immune ablation and stem-cell therapy in autoimmune disease Immunological reconstitution after high-dose immunosuppression and haematopoietic stem-cell transplantation

Table 1 Determinants of immune reconstitution after HDIT and SCT

Age-dependent thymopoiesis in children versus adults [5*,6,7,9,10,11]
Source of hematopoietic stem cells:
allogeneic versus autologous [8*];
bone marrow versus peripheral blood [8,13,41,42]
Mobilization protocol: G-CSF alone versus chemotherapy and G-CSF [42]
Conditioning regimen: myeloablative versus intensive
immunosuppressive [5**]
Manipulation of graft (ex vivo T-cell depletion or CD34 enrichment)
versus in vivo T-cell depletion versus nonmanipulation of graft
[5,16,17,18,19,20**]
Pre- and post-transplant treatment? [43]
Underlying rheumatic disease?

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