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Table 2 Potential pathologic functions of B lymphocytes in autoimmune disease

From: Roles of B cells in rheumatoid arthritis

Presentation of immune-complexed antigens to autoreactive T cells
Expression of adhesion and other costimulatory molecules that promote T cell activation
Synthesis of chemokines that induce leukocyte infiltration
Production of factors that initiate and sustain angiogenesis and granulation tissue formation
Release of autoantibodies that are directly or indirectly (via immune complex formation) destructive to tissues
Maintenance of a memory response to autoantigens