Paw swelling during CFA injection in control rats (SG VIII) and rats receiving POMC gene and electroporation (SG VI) and electroporation and paw CFA injection (SG VII). POMC gene injection and electroporation (SG VI) suppressed the swelling. Results are means ± SEM. Statistical comparisons between groups were made by analysis of variance; individual comparisons were made with the post-hoc test. *P < 0.05.