Functional associations of hypervariable (HV) genes in patients with juvenile rheumatoid arthritis (JRA). Tabular data from the HV gene analysis was analyzed using Pathway Assist software. The graphical output delineating a functionally related network of genes is shown. Genes that displayed increased variation in expression in JRA patients are represented as red ovals. Major biologic processes related to these genes are represented as yellow rectangles. JRA is represented as a yellow square to delineate genes directly associated with pathology. Intracellular objects upon which a given set of genes acts are represented as yellow ovals. White ovals represent genes that are functionally related to the genes used for analysis. White hexagons represent organelles functionally associated with the genes analyzed. Orange hexagons represent classes of small molecules associated with the genes analyzed. Green squares signify that a defined regulatory relationship exits between genes. Blue squares signify that a putative regulatory relationship between genes has been identified but not biochemically defined. +, positive regulation; -, negative regulation.