Table 3 Genes that distinguish patients with active juvenile rheumatoid arthritis by hypervariable gene analysis

U26173

IL3BP1

bZIP protein NF-IL3A (IL3BP1)

4.5E-06

Basic leucine zipper (bZIP) transcription factor; activates IL3 gene expression and can also repress transcription; binds to regulatory sequences in the promoters of the adenovirus E4, γ interferon (IFNG), and interleukin 3 (IL3) genes

X87689

G6

Putative p64 CLCP protein

0.00245

Nuclear chloride channel-27; intracellular chloride channel

Y00787

IL-8

IL-8

0.00307

Interleukin 8; cytokine that plays a role in chemoattraction and activation of neutrophils; has similarity to several platelet-derived factors

M62831

ETR101

Transcription factor ETR101

0.00336

Immediate early gene product induced by TPA stimulation in promyelocytic leukemia cell line HL-60 and in other leukemia cell lines

X83394

HLA-C

HLA-Cw*0704

0.00553

Heavy chain that associates with β₂-microglobulin; forms MHC class I complex that binds peptides to present them to CTLs

D88378

PSMF1

Proteasome inhibitor hPI31 subunit

0.00556

A protein inhibitor of the 20-S proteasome

U08815

SPA61

Spliceosomal protein (SAP 61)

0.0059

Spliceosome-associated protein 3a, subunit 3; component of the essential heterotrimeric splicing factor SF3a; contains a zinc finger

M55067

NCF-1

47-kDa autosomal granulomatous disease protein

0.0068

Neutrophil cytosol factor 1; cytosolic component of NADPH oxidase, required for neutrophil superoxide production

D42063

RANBP2

RanBP2

0.0073

Ran binding protein 2; component of the nuclear pore complex; has leucine-rich and cyclophilin-like domains, and zinc finger motifs

M80927

YKL40

Glycoprotein (GP-39 synovial protein)

0.00793

Cartilage glycoprotein-39; has similarity to chitinases

X06272

SRPR

Docking protein

0.00826

Signal recognition particle receptor (docking protein); binds the SRP complexed with the translating ribosome to prepare for translocation of the polypeptide across the rough endoplasmic reticulum membrane

D44497

Clabp

Actin-binding protein p57

0.00981

Coronin 1A; binds actin, involved in mitosis, cell motility, formation of phagocytic vacuoles and phagocytosis; has five WD domains

X86693

HEVIN

Hevin-like protein

0.01158

Expressed in high endothelial venules, may have antiadhesive properties and a role in leukocyte extravasation.

D86970

MAJN

TGFβ 1-induced antiapoptotic factor

0.01174

Protects against tumor necrosis factor-α (TNF)-induced apoptosis

X69391

Ribosomal protein L6

0.01251

mRNA for ribosomal protein L6

X76105

DAP

DAP-1 mRNA

0.01319

Death-associated protein; may mediate apoptosis induced by interferon-γ ; has proline-rich regions

Y08110

SORLA

Mosaic protein LR11

0.02155

Sortilin-related receptor; may be involved in the uptake of lipoproteins and proteases

D88153

HYA22

HYA22

0.02189

Protein with similarity to Saccharomyces cerevisiae Psr1p and Psr2p

D21267

SNAP-25

Synaptosomal-associated protein, 25 kDa

0.02199

Synaptosomal-associated protein, 25-kDa; involved in membrane fusion during exocytosis; member of the SNAP family of proteins

M11233

CPSD

Cathepsin D

0.02328

Cathepsin D; lysosomal aspartyl protease (acid protease)

D88827

ZNF#

Zinc finger protein FPM315

0.0244

C2H2-type zinc finger protein 263; may act as a transcriptional repressor; contains C2H2-type zinc fingers, and KRAB-A and LeR domains

U06452

MART-1

Melanoma antigen recognized by T cells

0.02575

Melan-A (melanoma antigen recognized by T cells 1)

X13403

OTF1

Octamer-binding protein Oct-1

0.02722

Ubiquitously expressed POU homeodomain transcription factor 1; binds to the octamer motif ATGCAAAT

X56976

UBE1X

Ubiquitin-activating enzyme E1

0.02928

Ubiquitin-activating enzyme E1; activates ubiquitin to mark cellular proteins for degradation; very strongly similar to murine Ube1x, which may function in DNA repair

X95325

CSDA

DNA-binding protein A variant

0.03421

Member of a family of transcriptional regulators; binds and represses the promoter of the GM-CSF gene; contains a cold-shock domain

X58536

HLA-C

HLA class I locus C heavy chain

0.035

Heavy chain that associates with β₂-microglobulin; forms MHC class I complex that binds peptides to present them to CTLs

U16031

IL-4-STAT

Transcription factor IL-4 Stat

0.03632

Signal transducer and activator of transcription 6, interleukin-4 induced; activates expression of the interleukin-4 receptor gene in response to interleukin-4 and mediates JAK kinase signal transduction; member of the STAT family