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Table 3 Genes that distinguish patients with active juvenile rheumatoid arthritis by hypervariable gene analysis

From: Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis

Gene bank Name Description F-testa Summary of function
U26173 IL3BP1 bZIP protein NF-IL3A (IL3BP1) 4.5E-06 Basic leucine zipper (bZIP) transcription factor; activates IL3 gene expression and can also repress transcription; binds to regulatory sequences in the promoters of the adenovirus E4, γ interferon (IFNG), and interleukin 3 (IL3) genes
X87689 G6 Putative p64 CLCP protein 0.00245 Nuclear chloride channel-27; intracellular chloride channel
Y00787 IL-8 IL-8 0.00307 Interleukin 8; cytokine that plays a role in chemoattraction and activation of neutrophils; has similarity to several platelet-derived factors
M62831 ETR101 Transcription factor ETR101 0.00336 Immediate early gene product induced by TPA stimulation in promyelocytic leukemia cell line HL-60 and in other leukemia cell lines
X83394 HLA-C HLA-Cw*0704 0.00553 Heavy chain that associates with β2-microglobulin; forms MHC class I complex that binds peptides to present them to CTLs
D88378 PSMF1 Proteasome inhibitor hPI31 subunit 0.00556 A protein inhibitor of the 20-S proteasome
U08815 SPA61 Spliceosomal protein (SAP 61) 0.0059 Spliceosome-associated protein 3a, subunit 3; component of the essential heterotrimeric splicing factor SF3a; contains a zinc finger
M55067 NCF-1 47-kDa autosomal granulomatous disease protein 0.0068 Neutrophil cytosol factor 1; cytosolic component of NADPH oxidase, required for neutrophil superoxide production
D42063 RANBP2 RanBP2 0.0073 Ran binding protein 2; component of the nuclear pore complex; has leucine-rich and cyclophilin-like domains, and zinc finger motifs
M80927 YKL40 Glycoprotein (GP-39 synovial protein) 0.00793 Cartilage glycoprotein-39; has similarity to chitinases
X06272 SRPR Docking protein 0.00826 Signal recognition particle receptor (docking protein); binds the SRP complexed with the translating ribosome to prepare for translocation of the polypeptide across the rough endoplasmic reticulum membrane
D44497 Clabp Actin-binding protein p57 0.00981 Coronin 1A; binds actin, involved in mitosis, cell motility, formation of phagocytic vacuoles and phagocytosis; has five WD domains
X86693 HEVIN Hevin-like protein 0.01158 Expressed in high endothelial venules, may have antiadhesive properties and a role in leukocyte extravasation.
D86970 MAJN TGFβ 1-induced antiapoptotic factor 0.01174 Protects against tumor necrosis factor-α (TNF)-induced apoptosis
X69391   Ribosomal protein L6 0.01251 mRNA for ribosomal protein L6
X76105 DAP DAP-1 mRNA 0.01319 Death-associated protein; may mediate apoptosis induced by interferon-γ ; has proline-rich regions
Y08110 SORLA Mosaic protein LR11 0.02155 Sortilin-related receptor; may be involved in the uptake of lipoproteins and proteases
D88153 HYA22 HYA22 0.02189 Protein with similarity to Saccharomyces cerevisiae Psr1p and Psr2p
D21267 SNAP-25 Synaptosomal-associated protein, 25 kDa 0.02199 Synaptosomal-associated protein, 25-kDa; involved in membrane fusion during exocytosis; member of the SNAP family of proteins
M11233 CPSD Cathepsin D 0.02328 Cathepsin D; lysosomal aspartyl protease (acid protease)
D88827 ZNF# Zinc finger protein FPM315 0.0244 C2H2-type zinc finger protein 263; may act as a transcriptional repressor; contains C2H2-type zinc fingers, and KRAB-A and LeR domains
U06452 MART-1 Melanoma antigen recognized by T cells 0.02575 Melan-A (melanoma antigen recognized by T cells 1)
X13403 OTF1 Octamer-binding protein Oct-1 0.02722 Ubiquitously expressed POU homeodomain transcription factor 1; binds to the octamer motif ATGCAAAT
X56976 UBE1X Ubiquitin-activating enzyme E1 0.02928 Ubiquitin-activating enzyme E1; activates ubiquitin to mark cellular proteins for degradation; very strongly similar to murine Ube1x, which may function in DNA repair
X95325 CSDA DNA-binding protein A variant 0.03421 Member of a family of transcriptional regulators; binds and represses the promoter of the GM-CSF gene; contains a cold-shock domain
X58536 HLA-C HLA class I locus C heavy chain 0.035 Heavy chain that associates with β2-microglobulin; forms MHC class I complex that binds peptides to present them to CTLs
U16031 IL-4-STAT Transcription factor IL-4 Stat 0.03632 Signal transducer and activator of transcription 6, interleukin-4 induced; activates expression of the interleukin-4 receptor gene in response to interleukin-4 and mediates JAK kinase signal transduction; member of the STAT family
  1. aStatistical parameter assessing the relative variation in patients with active disease vs healthy controls.