Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis

Jarvis, James N; Dozmorov, Igor; Jiang, Kaiyu; Frank, Mark Barton; Szodoray, Peter; Alex, Philip; Centola, Michael

doi:10.1186/ar1018

Arthritis Research & Therapy

Table 4 Genes that distinguish children with active juvenile rheumatoid arthritis in discriminant function analysis

From: Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis

Gene bank	Name	Description	AverAD	AverHC	Partial Wilks λ	Summary of function
M11147	FTL	Ferritin L chain	23.25	82.87	0.008	Ferritin light polypeptide; iron storage protein
D23661	RPL37	Ribosomal protein L37	65.72	73.62	0.027	Ribosomal protein L37; component of the large 60-S ribosomal subunit
M59907	GRANULOPHYSIN	CD63	27.03	21.75	0.006	Melanoma-associated antigen; may function as a blood platelet activation marker
M20681	SLC2A3P	SLC2A3 glucose transporter	26.23	29.56	0.004	Facilitated glucose transporter
Y14737	HDC	Immunoglobulin heavy constant γ3	22.24	56.99	0.002	Constant region of heavy chain of IgG3
U14747	VSNL1	VSNL1	22.05	12.47	0.174	Visinin-like protein 1; may bind calcium
X02812	TGFB1	TGFB1	20.11	30.1	0.005	Transforming growth factor β1; regulates cell proliferation, differentiation, and apoptosis
Y00787	IL-8	IL-8	19.36	54.2	0.018	Interleukin 8; cytokine that plays a role in chemoattraction and activation of neutrophils
AF026939	RIGG	IFNIT4 interferon-induced protein	16.68	1.97	0.026	Interferon-induced protein
X13403	OTF1	Octamer-binding protein Oct-1	15.46	14.96	0.005	Ubiquitously expressed POU homeodomain transcription factor 1
Y08110	SORLA	Sortilin-related receptor	14.48	28.66	0.002	Sortilin-related receptor; may be involved in the uptake of lipoproteins and proteases
U75283	SR-BP1	Sigma receptor	11.46	5.34	0.004	Type I sigma receptor; transmembrane protein that interacts with psychotomimetic drugs, including cocaine and amphetamines
X02492	15-Jun	Interferon-inducible fragment	10.3	1.88	0.024	Induced by α and β interferon; hydrophobic
M64722	APOJ	Clusterin	9.74	4.84	0.003	Clusterin, glycoprotein found in high-density lipoproteins and endocrine and neuronal granules; has a role in the terminal complement reaction
M55646	IL1RN	IL-1 receptor antagonist	7.03	3.69	0.056	Interleukin 1 receptor antagonist; binds to and inhibits the IL-1 receptor
X57198	TFIIS	Transcription elongation factor A	6.38	7.9	0.005	Transcription elongation factor A (SII); stimulates the activity of the RNA polymerase II elongation complex
AF043233	HPECT1	Caco-2 oligopeptide transporter	5.49	2.87	0.004	H(+)-coupled peptide transporter; absorbs small peptides produced by digestion of dietary proteins and may transport β-lactam antibiotics
U26173	IL3BP1	Interleukin 3 regulated nuclear factor	5.4	6.58	0.033	Basic leucine zipper (bZIP) transcription factor; activates IL3 gene expression and can also repress transcription; binds to regulatory sequences in the promoters of the adenovirus E4, γ interferon (IFNG), and interleukin 3 (IL3) genes
X05997		Gastric lipase	5.27	28.58	0.008	Digestion of dietary triglycerides in the gastrointestinal tract

AverAD, AverHC, average expression level (defined as the number of standard deviations from mean of background) in untreated patients with active disease and in healthy controls, respectively. The discriminative power of each gene can also be characterized by the partial Wilks λ coefficient. This value is equal to the ratio of within-group differences in expression to within- and between-group differences in expression. It ranges from 1.0 (no discriminatory power) to 0.0 (perfect discriminatory power). ND, none detected.

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ISSN: 1478-6362

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