Signalling alteration | Role in T cells |
---|---|
Intracellular free Ca2+ | Early T-cell activation |
Myo-inositol 1,4,5-trisphosphate production | Calcium release |
Protein kinase C isoform translocation | T-cell activation |
CD69 expression | Activation surface marker |
CD71 expression | Activation surface marker |
CD28 expression | Costimulatory molecule |
Membrane fluidity | Protein trafficking |
Cholesterol content | Lipid rafts movement |
Rafts-associated proteins | Early T-cell activation, immune synapse formation |
NF-AT distribution | Calcium signalling |
Regulation of cellular cholesterol | Molecule sorting, lipid rafts formation |
Rafts coalescence | T-cell activation, immune synapse formation |
Lck activation | ZAP-70, ITAM phosphorylation |
Linker of activated T cells activation | Signalling platform |
Fyn activation | ZAP-70, ITAM phosphorylation |
ZAP-70 activation | Linker of activated T cells activation |
Extracellular signal-regulated kinase activation | Late T-cell activation, proliferation |
p38 activation | Late T-cell activation, proliferation |
Proteasome activity | NF-κB relocalization |