Table 3 Guidelines for conditioning regimens before HSC transplantation
From: Immune ablation and stem-cell therapy in autoimmune disease - Clinical experience
Cyclophosphamide 50 mg/kg for 4 days at a 1-h infusion from days -5 |
|---|
   to -2 before the transplantation; this is standard treatment for |
   aplastic anaemia. Antithymocyte globulin may or may not be added |
Cyclosphamide 60 mg/kg for 2 days at 1-h infusion followed by total |
   body irradiation, as currently used at the treating centre |
Busulfan 16 mg/kg orally over 4 days in 16 doses of 1 mg/kg each, |
   followed by cyclophosphamide 60 mg/kg a 1-h infusion for 2 days; |
   anticonvulsant prophylaxis is required |
Combination chemotherapy: BEAM (BCNU 300 mg/m2 intravenously |
   day -7; VP-16 250 mg/m2 per day, divided over two doses each |
   day, from days -7 to -4; Ara-C 200 mg/m2 per day, divided over |
   two doses each day, on days -7, -6 and -4; melphalan 140 |
   mg/m2 intravenously on day -3) |