Table 1 IFN-γ production by PBMCs from patients with rheumatoid arthritis in response to IL-12 and IL-18
From: Decreased response to IL-12 and IL-18 of peripheral blood cells in rheumatoid arthritis
Variable | Younger patients | Older patients |
|---|---|---|
No. of patients | 7 | 7 |
Mean age (years) | 40.1 ± 5.0 | 65.7 ± 4.6 |
Disease duration (years) | 5.5 ± 2.3 | 17.7 ± 6.4 |
C-reactive protein (mg/l) | 13.4 ± 2.0 | 13.9 ± 5.0 |
IFN-γ production (ng/ml) | ||
In medium alone | 0.05 ± 0.03 | 0.05 ± 0.03 |
With IL-12 | 0.56 ± 0.14 | 0.50 ± 0.17 |
With IL-12 + IL-18 | 0.83 ± 0.17 | 0.48 ± 0.14 |
With IL-12 + IL-18BP | 0.53 ± 0.19 | 0.36 ± 0.15 |