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Table 1 Autoantibodies in Nijmegen sera from a cohort of patients with Sjögren's syndrome

From: Anti-α-fodrin antibodies do not add much to the diagnosis of Sjögren's syndrome

  IgAa IgGb       
Pt no. Nijmegen Hanoverc Nijmegen Hanoverc IBd IPe Ro60f Lag LFSh Comorbidity
Primary Sjögren's syndrome
1 + + + - - - + - +  
2 - - - - - - - + +  
3 + - - - - - - - +  
4 + + + - - - + - +  
5 + + + - + + + + +  
6 + - - - - + + + +  
7 + - - - - - - - +  
8 - + - - - - - - +  
9 - + + - - - + - +  
10 + + + - - + + + +  
11 - - - - - - + + +  
12 - - - - + - + - +  
13 - - + - - - + + +  
14 - - - - + + + + +  
15 - - + - - - + + +  
16 - - - - + - - - +  
17 - - + - - - + + +  
18 + + - - - - - + +  
19 - - - - + - - - +  
20 + + + + - - + + +  
21 - - + + - - + + +  
Secondary Sjögren's syndrome
22 + + + - + + + + + SLE
23 + + + + + + + + + SLE
24 - - - - - - + - + SLE
25 + + + + + + - - + SLE
26 + + + - + - + + + SSc
27 - - + - - - + - + DM
  1. aIgA, ELISA measuring presence of IgA antibodies directed against α-fodrin; bIgG, ELISA measuring presence of IgG antibodies directed against α-fodrin; cfindings in Hanover for the sera originally tested in Nijmegen; dIB, immunoblotting results (α-fodrin); eIP, protein immunoprecipitation results (α-fodrin); fRo60, ELISA measuring presence of antibodies directed against Ro60-antigen; gLa, ELISA measuring presence of antibodies directed against La-antigen; hLFS, lymphocytic focus score ≥ 1.0 in sublabial minor salivary glands biopsy. DM, dermatomyositis; Pt, patient; SSc, systemic sclerosis; SLE, systemic lupus erythematosus.