Figure 9

Comparison of the effect of p38 mitogen-activated protein kinase (SB 203580 [SB]) with cyclooxygenase-2 (Sc-58125 [Sc]) inhibition on IL-1 action to diminish chondrocyte proliferation. Cells were treated as for Fig. 4, but with the addition of Sc-58125 at a final concentration of 0.5 μM 30 min before IL-1. Values are the mean ± standard error of n = 6–12. *P < 0.05 versus IL-1 alone. FCS, fetal calf serum; IGF, insulin-like growth factor 1; TGF, transforming growth factor beta.