Chondrocyte response to growth factors is modulated by p38 mitogen-activated protein kinase inhibition

Table 2 Summary of effects of p38 MAPK and COX-2 inhibition on chondrocyte proliferation

	Lapine chondrocyte proliferation
	Basal	+ IGF-1/FCS
SB	+	+
IL-1	No change	- -
IL-1 + SB*	+	+ +
IL-1 + L-NMA*	No change	+
IL-1 + Sc-58125*	No change	No change

*Relative to IL-1 alone. FCS, fetal calf serum; IGF-1, insulin-like growth factor 1; L-NMA, N-monomethyl-L-arginine; SB, SB 203580.

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