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Figure 6 | Arthritis Res Ther

Figure 6

From: Enhanced expression of interferon-inducible protein 10 associated with Th1 profiles of chemokine receptor in autoimmune pulmonary inflammation of MRL/lprmice

Figure 6

Phenotype analyses of CXCR3-expressing infiltrating cells in the lungs of 1- and 4-month-old MRL/lpr, MRL/+, and B6 mice. Mononuclear leukocytes isolated from the lungs were stained with antibodies against CD3, CD4, CD8, B220, macrophage, or CXCR3. The cells were gated for either (a) CD3+CD4+, (b) macrophage, (c) CD3+CD8+, or (d) CD3+B220+, and were analyzed for the level of CXCR3 expression by flow cytometry. (a–d) Histograms of the lungs from 4-month-old mice are representative of three independent experiments. (e) Mean fluorescence intensity of CXCR3 expression (M2) on gated cells, expressed as mean ± SEM (n = 3); M1, background intensity of isotype-matched control staining. CXCR3 expression was significantly higher on CD4+CD3+ T cells and macrophages in 4-month-old MRL/lpr mice lungs than in MRL/+ and B6 mice (*P < 0.05).

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