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Table 3 Epitope mapping of giantin

From: Giantin is the major Golgi autoantigen in human anti-Golgi complex sera

Recombinant fragments Total positive sera (n [%]) Low-positive sera (%) High-positive sera (%)
P1, aa 39–1040 (1001 aa) 12 (30.0) 7/12 (58.3) 5/12 (41.7)
P2, aa 851–1450 (599 aa) 11 (27.5) 8/11 (72.7) 3/11 (27.3)
P3, aa 1435–2204 (769 aa) 11 (27.5) 7/11 (63.6) 4/11 (36.4)
P4, aa 2019–2568 (549 aa) 7 (17.5) 3/7 (42.9) 4/7 (47.1)
P5, aa 2550–2843 (293 aa) 15 (37.5) 15/15 (100) 0
P6, aa 2818–3259 (441 aa) 22 (55.0) 22/22 (100) 0
  1. A total of 40 antigiantin positive human sera were analyzed for reactivity in ELISA. Cutoff value for a positive reaction: the mean optical density (OD) of normal human sera +3 standard deviations (SDs). Low-positive: the OD between the mean of normal sera +3 SDs to +15 SDs. High-positive: OD greater than the mean of normal sera +15 SDs. aa, amino acids.
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