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Figure 4 | Arthritis Res Ther

Figure 4

From: Inhibition of established collagen-induced arthritis with a tumour necrosis factor-α inhibitor expressed from a self-contained doxycycline regulated plasmid

Figure 4

Effect of pcdTNFR on progression of collagen-induced arthritis. Development of arthritis was monitored by (a, c and e) clinical score and (b, d and f) hind paw swelling in DBA/1 mice. Treatment was administered after onset of clinical arthritis. All mice injected with pcdTNFR (; n = 16) and pcDNA3 (□; n = 11) are depicted in panels a and b; those with a clinical score less than 2 at the time of DNA injection are presented in panels c and d; and those with a clinical score above 2 when treatment was initiated are plotted in panels e and f. Significant differences between the pcdTNFR and pcDNA3 group (P ≤ 0.05) are indicated (*).

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