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Figure 5 | Arthritis Res Ther

Figure 5

From: Inhibition of established collagen-induced arthritis with a tumour necrosis factor-α inhibitor expressed from a self-contained doxycycline regulated plasmid

Figure 5

Gene therapy treatment of collagen-induced arthritis (CIA) with regulated expression of dimeric human tumour necrosis factor receptor 2 (dTNFR). Progression of CIA was monitored by clinical score (a, c and e) and hind paw swelling (b, d and f) in groups that received pGTRTEmpty plus doxycycline (□; n = 16), pGTRTT without doxycycline (; n = 16) and pGTRTT plus doxycycline (; n = 17). Treatment was administered after onset of clinical arthritis. All treated animals are illustrated in panels a and b; those with a clinical score of 2 or less at the time of DNA injection (day 27) are illustrated in panels c and d; and animals with a clinical score greater than 2 at the start of treatment are depicted in panels e and f. Significant differences between the pGTRTT plus doxycycline and the pGTRTT without doxycycline groups are indicated (*P < 0.05, **P < 0.02 and ***P < 0.01).

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