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Table 1 Anticollagen II antibodies in mice with collagen-induced arthritis

From: Inhibition of established collagen-induced arthritis with a tumour necrosis factor-α inhibitor expressed from a self-contained doxycycline regulated plasmid

  Anti-CII antibodies
Treatment Total IgG1 IgG1 IgG2a IgG2a : IgG1 ratio
GTRTEmpty + doxycycline 0.64 ± 0.11 2.0 ± 0.7 1.6 ± 0.3 1.3 ± 0.4
GTRTT – doxycycline 1.1 ± 0.4 1.7 ± 0.5 1.5 ± 0.5 1.4 ± 0.3
GTRTT + doxycycline 1.1 ± 0.3 1.6 ± 0.3 1.3 ± 0.2 1.4 ± 0.4
  1. Results are presented from at least six animals in each group. Anti-CII IgG levels in sera collected at the end of the experiment (day 40) was determined by ELISA, with values expressed relative to those obtained for a pooled sample from untreated mice at the same time point. CII, collagen type II.
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