| Anti-CII antibodies |
---|
Treatment | Total IgG1 | IgG1 | IgG2a | IgG2a : IgG1 ratio |
---|
GTRTEmpty + doxycycline | 0.64 ± 0.11 | 2.0 ± 0.7 | 1.6 ± 0.3 | 1.3 ± 0.4 |
GTRTT – doxycycline | 1.1 ± 0.4 | 1.7 ± 0.5 | 1.5 ± 0.5 | 1.4 ± 0.3 |
GTRTT + doxycycline | 1.1 ± 0.3 | 1.6 ± 0.3 | 1.3 ± 0.2 | 1.4 ± 0.4 |
- Results are presented from at least six animals in each group. Anti-CII IgG levels in sera collected at the end of the experiment (day 40) was determined by ELISA, with values expressed relative to those obtained for a pooled sample from untreated mice at the same time point. CII, collagen type II.