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Table 1 Anticollagen II antibodies in mice with collagen-induced arthritis

From: Inhibition of established collagen-induced arthritis with a tumour necrosis factor-α inhibitor expressed from a self-contained doxycycline regulated plasmid

 

Anti-CII antibodies

Treatment

Total IgG1

IgG1

IgG2a

IgG2a : IgG1 ratio

GTRTEmpty + doxycycline

0.64 ± 0.11

2.0 ± 0.7

1.6 ± 0.3

1.3 ± 0.4

GTRTT – doxycycline

1.1 ± 0.4

1.7 ± 0.5

1.5 ± 0.5

1.4 ± 0.3

GTRTT + doxycycline

1.1 ± 0.3

1.6 ± 0.3

1.3 ± 0.2

1.4 ± 0.4

  1. Results are presented from at least six animals in each group. Anti-CII IgG levels in sera collected at the end of the experiment (day 40) was determined by ELISA, with values expressed relative to those obtained for a pooled sample from untreated mice at the same time point. CII, collagen type II.