Skip to main content

Table 2 Cytokine release from draining lymph node cells of collagen-induced arthritis mice

From: Inhibition of established collagen-induced arthritis with a tumour necrosis factor-α inhibitor expressed from a self-contained doxycycline regulated plasmid

  Cytokine release from DLN cells
Treatment IFN-γ (ng/ml): 48 hour CII IFN-γ (ng/ml): 48 hour ConA IL-4 (pg/ml): 48 hour CII IL-4 (pg/ml): 48 hour ConA
GTRTEmpty + doxycycline 0.41 ± 0.03 4.2 ± 1.1 11.9 ± 3.2 33.2 ± 8.8
GTRTT – doxycycline 0.66 ± 0.15 2.4 ± 0.8 6.4 ± 1.5 24.4 ± 6.7
GTRTT + doxycycline 0.49 ± 0.04 2.8 ± 0.9 9.0 ± 1.6 21.5 ± 2.4
  1. Results are presented from at least six animals in each group. Cytokine release from draining lymph node (DLN) cells was induced by 48 hours of stimulation with CII or ConA and was measured by ELISA. CII, collagen type II.
\