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Figure 2 | Arthritis Res Ther

Figure 2

From: IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways

Figure 2

IL-17 induces production of (b) IL-6 and (c) IL-8, but not of (a) IL-15, by synovial fibroblasts from five RA patients. In vitro stimulation with 10 ng/ml IL-17 for 12 hours induced two- to six-fold increases in the levels of IL-6 and IL-8 in the culture supernatant of synovial fibroblasts isolated from RA patients, while the level of IL-15 remained unchanged. Open bar, unstimulated FLS; filled bar, IL-17-stimulated FLS. FLS, fibroblast-like synoviocytes; RA, rheumatoid arthritis.

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