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Figure 3 | Arthritis Res Ther

Figure 3

From: IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways

Figure 3

Induction of (a) IL-6 and (b) IL-8 in RA FLS after treatment with various proinflammatory cytokines. Cells were stimulated with 10 ng/ml of IL-15, IL-17, IL-18, TGF-β, or IL-1β, or with 1000 U/ml IFN-γ for 24 hours and assayed for the production of IL-6 and IL-8 in culture supernatants by sandwich ELISA. Values represent average from triplicate cultures. Cell, unstimulated FLS; IFN, interferon; RA, rheumatoid arthritis; FLS, fibroblast-like synoviocyte(s); TGF, transforming growth factor.

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