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Figure 6 | Arthritis Res Ther

Figure 6

From: IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways

Figure 6

Effect of MAPK blockade on the IL-17-mediated induction of (a) IL-6 and (b) IL-8 in FLS from two patients with RA. FLS were cultured in triplicate with or without 10 ng/ml IL-17 for 24 hours and assayed for the production of IL-6 and IL-8 by sandwich ELISA. Effects of blocking MAPK activation were investigated by adding 1 or 10 nM SB203580 at the time of IL-17 stimulation. Cell, unstimulated FLS; FLS, fibroblast-like synoviocytes; MAPK, mitogen-activated protein kinase; RA, rheumatoid arthritis.

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