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Figure 7 | Arthritis Res Ther

Figure 7

From: IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways

Figure 7

IL-17-mediated induction of (a) IL-6 and (b) IL-8 involves PI3-kinase and Akt signaling in FLS from two patients with RA. Treating the cells with 20 μM LY294002, a chemical inhibitor of PI3-kinase, abolished the IL-17-induced increase in the production of IL-6 and IL-8 from RA FLS. White bars, unstimulated control cells; gray bars, IL-17-stimulated FLS; black bars, cells treated with IL-17 and LY294002. FLS, fibroblast-like synoviocytes; PI3-kinase, phosphatidylinositol 3-kinase; RA, rheumatoid arthritis.

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