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Table 2 B-cell clones from the different anatomical localisations are shown with closest identified VH germline gene segment and its homology

From: IgVH genes from different anatomical regions, with different histopathological patterns, of a rheumatoid arthritis patient suggest cyclic re-entry of mature synovial B-cells in the hypermutation process

Location Clone VH family Germline Homology (%)
Left peroneal tendon     
  K194/1# 1 IgHV1-18 * 01 79.4
  K194/3 1 IgHV1-69 * 01 73.6
  K194/4 1 IgHV1-3 * 01 96.6
  K194/5 1 IgHV1-69 * 01 66.9
  K194/6 1 IgHV1-18 * 01 88.2
  K194/8 2 IgHV2-70 * 11 98.1
  K194/9 2 IgHV2-70 * 01 92.0
  K194/23 4 IgHV4-30-1/4-31 * 02 100.0
  K194/24 3 IgHV3-53 * 02 95.1
  K194/25 4 IgHV4-59 * 01 91.0
  K194/26 4 IgHV4-30-4 * 06 89.0
  K194/27 5 IgHV5-51 * 01 96.1
  K194/28 5 IgHV5-51 * 01 85.0
  K194/30## 5 IgHV5-51 * 01 P
  K194/31 5 IgHV5-51 * 01 93.8
  K194/33 5 IgHV5-51 * 01 P
  K194/42 5 IgHV5-51 * 01 98.0
  K194/81 2 IgHV2-70 * 01 P
Cubita     
  K194/57## 1 IgHV1-18 * 01 // IgHV1-46 * 01 ND
  K194/58 1 IgHV1-46 * 01 66.5
  K194/62 1 IgHV1-18 * 01 91.6
  K194/67## 1 IgHV1-18 * 01 // IgHV1-2 * 02 ND
  K194/72 1 IgHV1-69 * 01 95.3
  K194/76 1 IgHV1-18 * 01 97.9
  K194/77 1 IgHV1-8 * 01 94.5
  K194/79 1 IgHV1-18 * 01 75.7
  K194/82 1 IgHV1-46 * 01 80.3
  K194/88 1 IgHV1-2 * 02 91.2
  K194/89 1 IgHV1-3 * 01 86.0
  K194/92 1 IgHV1-8 * 01 88.7
  K194/95 1 IgHV1-69 * 01 76.9
  K194/98 1 IgHV1-8 * 01 96.2
  K194/99 ## 2 IgHV2-70 * 01 92.0
  K194/100 4 IgHV4-30-1/4-31 * 02 97.0
  K194/101 4 IgHV4-30-1/4-31 * 02 97.0
  K194/102 4 IgHV4-30-1/4-31 * 02 97.0
  K194/103 4 IgHV4-30-1/4-31 * 02 98.0
  K194/104 6 IgHV6-1 * 01 88.0
Right peroneal tendon     
  K194/109## 1 IgHV1-8 * 01//IgHV1-18 * 01 ND
  K194/111# 1 IgHV1-18 * 01 77.0
  K194/114 1 IgHV1-18 * 01 79.0
  K194/117 1 IgHV1-18 * 01 93.0
  K194/118 1 IgHV1-18 * 01 88.0
  K194/119 ## 1 IgHV1-18 * 01 96.0
  K194/120 1 IgHV1-18 * 01 P
  K194/121 2 IgHV2-70 * 01 97.0
  K194/122 5 IgHV5-51 * 01 94.0
  K194/123 5 IgHV5-51 * 01 87.0
  K194/124 5 IgHV5-51 * 03 92.0
  K194/125 5 IgHV5-51 * 03 98.0
  K194/126 ## 5 IgHV5-51 * 01 P
  K194/127 5 IgHV5-51 * 01 94.0
  K194/130 5 IgHV5-51 * 01 P
  K194/135 5 IgHV5-51 * 01 P
  K194/136 5 IgHV5-51 * 01 98.0
  1. #, Clone presenting amino acid deletions; ##, mixed molecule; P,pseudogene; ND, not determined; Bold indicates amplification Fromgenomic DNA.