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Table 1 Development of CIA and antibody responses to CII

From: T cells that are naturally tolerant to cartilage-derived type II collagen are involved in the development of collagen-induced arthritis

    Arthritis Onset (day   Anti-CII IgG (μ g/ml
    (frequency of max score of   in serum 35 days
Sex Mice   CIA) arthritic mice) Severity after immunization)
Male Lm Sham 11/11 25 ± 4 8.4 ± 1.5 182 ± 73
   Tx 9/9 33 ± 9 9.1 ± 2.0 328 ± 206
  MMC Sham 2/8 34 ± 6 4.5 ± 5.0 63 ± 112
   Tx 3/8 56 ± 22 2.0 ± 1.0 40 ± 49
Female Lm Sham 6/7 35 ± 15 7.2 ± 2.8 614 ± 413
   Tx 7/8 43 ± 16 7.6 ± 3.0 423 ± 273
  MMC Sham 0/8 - - 30 ± 25
   Tx 2/10 64 ± 1.4 3.0 ± 2.8 24 ± 33
  1. lm, nontransgenic littermates; Sham, sham-operated; Tx, thymectomized. Where applicable, values are expressed as mean ± standard deviation.