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Table 1 Development of CIA and antibody responses to CII

From: T cells that are naturally tolerant to cartilage-derived type II collagen are involved in the development of collagen-induced arthritis

   

Arthritis

Onset (day

 

Anti-CII IgG (ÎĽ g/ml

   

(frequency of

max score of

 

in serum 35 days

Sex

Mice

 

CIA)

arthritic mice)

Severity

after immunization)

Male

Lm

Sham

11/11

25 ± 4

8.4 ± 1.5

182 ± 73

  

Tx

9/9

33 ± 9

9.1 ± 2.0

328 ± 206

 

MMC

Sham

2/8

34 ± 6

4.5 ± 5.0

63 ± 112

  

Tx

3/8

56 ± 22

2.0 ± 1.0

40 ± 49

Female

Lm

Sham

6/7

35 ± 15

7.2 ± 2.8

614 ± 413

  

Tx

7/8

43 ± 16

7.6 ± 3.0

423 ± 273

 

MMC

Sham

0/8

-

-

30 ± 25

  

Tx

2/10

64 ± 1.4

3.0 ± 2.8

24 ± 33

  1. lm, nontransgenic littermates; Sham, sham-operated; Tx, thymectomized. Where applicable, values are expressed as mean ± standard deviation.