|  |  | Arthritis | Onset (day |  | Anti-CII IgG (μ g/ml |
---|---|---|---|---|---|---|
 |  |  | (frequency of | max score of |  | in serum 35 days |
Sex | Mice | Â | CIA) | arthritic mice) | Severity | after immunization) |
Male | Lm | Sham | 11/11 | 25 ± 4 | 8.4 ± 1.5 | 182 ± 73 |
 |  | Tx | 9/9 | 33 ± 9 | 9.1 ± 2.0 | 328 ± 206 |
 | MMC | Sham | 2/8 | 34 ± 6 | 4.5 ± 5.0 | 63 ± 112 |
 |  | Tx | 3/8 | 56 ± 22 | 2.0 ± 1.0 | 40 ± 49 |
Female | Lm | Sham | 6/7 | 35 ± 15 | 7.2 ± 2.8 | 614 ± 413 |
 |  | Tx | 7/8 | 43 ± 16 | 7.6 ± 3.0 | 423 ± 273 |
 | MMC | Sham | 0/8 | - | - | 30 ± 25 |
 |  | Tx | 2/10 | 64 ± 1.4 | 3.0 ± 2.8 | 24 ± 33 |