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Table 1 Clinical outcome and treatment-related morbidity of patients with polychondritis or SLE in complete remission

From: Autologous stem-cell transplantation in refractory autoimmune diseases after in vivo immunoablation and ex vivo depletion of mononuclear cells

Patient* Follow up (months) ANA Anti-double-stranded DNA ELISA (U/ml) CL-IF Cardiolipin†§ (U/ml) IgG/IgM Other parameters Complement (md/dl) C3/C4 Steroid dosage (mg/day)†¶ Karnofsky score (%) ECLAM score Side effects during immunoablation
1     PC/female/41 years/1985 21 No relevance No relevance No relevance Tracheal involvement, costosternal pain, arthralgias No relevance 62.5 60 No relevance SIRS**: WHO grade IV Local infection Interstitial pneumonia and capillary leakage DIC Reactivation of gastrointestinal ulcer
        
      Complete resolution   3 100   
2 SLE/female/27 years/1987 19 1:5120 518  /  1:64 38    /    54 82    /    10 35 40 6.5 SIRS**: WHO grade IV Septicaemia and pneumonia in aplasia: WHO grade I Flares of disease (abdominal vasculitis, arthralgias, serositis)
      ↓         ↓ ↓         ↓   ↓          ↓  
   Negligible <31     <31   140       22 5 100 2  
3 SLE/female/48 years/1993 16 1:5120 5040 / 1:128 88 / 379 α -Ro+ 122   /   14 20 60 6 SIRS**: WHO grade IV Septicaemia Local infection Liver haematoma: WHO grade II SIRS**: WHO grade IV
      ↓         ↓ ↓         ↓ ↓         ↓  
   1:80 <31     <31 164      27 4 100 2  
4    SLE/male/37 years/1989 10 1:2560 976 / 1:128 33   /   56 α-Ro/  Proteinuria α-La+   8.8 g/day <44  /  <5 100 70 10  
      ↓         ↓ ↓         ↓   ↓            ↓ ↓         ↓  
   1:160 <31     <31 0.8 g/day 120     22 5 100 2  
  1. *Characteristics: number/disease/sex/age/year of diagnosis. Values above the arrow represent the admission values and those below the arrow represent the present status. ELISA cut-off was 118 iU/ml. §The cut-offs for IgG and IgM anticardiolipin were 48 and 44 U/ml, respectively. Doses corresponding to prednisolone equivalents. **SIRS due to application of cyclophosphamide and ATG. CL-IF, Crithidia luciliae immunofluorescence; PC, relapsing polychondritis; DIC, disseminated intravascular coagulation; ELISA, enzyme-linked immunosorbent assay; SIRS, systemic inflammatory response syndrome; WHO, World Health Organization.