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Table 1 Soluble mediators regulating fibroblast migration

From: Fibroblast biology Signals targeting the synovial fibroblast in arthritis

Effect Factor Cellular or tissue source Reference
+ TNF-α Macrophage, activated monocyte, B cell, T cell, fibroblast [2]
+ IL-4 T cell, mast cell, bone marrow stromal cell [3]
+ PDGF-AA, -BB, -AB Platelet, macrophage, endothelial cell, skeletal muscle cell, fibroblast, vascular smooth [3]
   muscle cell, glial cell, type I astrocyte, myoblast, kidney, epithelial cell, mesangial cell  
+ TGF-β Platelet, macrophage, T cell, skeletal muscle cell, fibroblast [4]
+ bFGF Brain, retina, bone matrix, endothelial cell, macrophage [3]
+ EGF Granulocyte, ectodermal cell, kidney, duodenal gland, platelet [5]
+ Neurokinin A Nerve cell [3]
+ CGRP Nerve cell [6]
+ Endothelin-1 and -3 Endothelial cell, macrophage, fibroblast, many other cells [3]
+ β -thromboglobulin Platelet, megakaryocyte [1]
+ Platelet factor 4 Platelet, megakaryocyte [1]
  LTB4 Myeloid cells, from transported LTA4 in many nonmyeloid and nonhematopoietic cells [3]
+ IGF-I (SmC) Fibroblast, skeletal cell, liver, endothelial cell, T cell [7]
+ IGF-II (MSA) Liver [3]
+ Matrix proteins   
     Collagen ECM [8]
     Fibronectin ECM [9]
     Elastin ECM [10]
+ Serum derived Complement (C5) [11,12]
  chemotactic factor   
  for fibroblasts   
- Interferon T lymphocyte, NK cell (interferon-γ), all cells (interferon-α) [13]
- Retinoids   [14]
- Neutrophil factor Neutrophil [15]
  1. +, Stimulation; -, inhibition. bFGF, basic fibroblast growth factor; CGRP, calcitonin gene-related peptide; ECM, extracellular matrix; EGF, epidermal growth factor; IGF, insulin-like growth factor; IL, interleukin; LTA, leukotriene A; LTB, leukotriene B; NK, natural killer; PDGF, platelet derived growth factor; TGF, transforming growth factor; TNF, tumor necrosis factor.