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Table 3 Interactions between extracellular matrix (ECM) proteins and fibroblast-like synoviocytes (FLS)

From: Fibroblast biology Signals targeting the synovial fibroblast in arthritis

ECM Effect Reference
Laminin (Ln) Ln is synthesized in rat and human FLS, and is involved in FLS adhesion [46]
  FLS adhesion to Ln shows enhanced proliferative ability in response to PDGF [47]
  RA-FLS bind to Ln more strongly than normal FLS, with monoclonal antibodies to integrin α 3, α 6, [48]
  β 1 subunits partly blocking this adhesion  
Fibronectin (Fn) FLS plated on the substrate containing Fn show extensive focus formation, and enhanced adhesion [49]
  and proliferation  
  CS-1 Fn correlates with FLS proliferation [50]
  ED-A Fn is associated with activation of FLS [44]
  FLS adhering to Fn show higher proliferative ability in response to PDGF [43]
  Adhesion to Fn through integrin α 5β 1 downregulates the collagenase expression in human FLS [47]
  RA-FLS bind more strongly to Fn than normal FLS; anti-α 5, or β 1 monoclonal antibodies block the [48]
  adhesion  
  Rabbit FLS cultured on the substrate containing Fn fragment show upregulated expression of [51]
  procollagenase and prostromelysin  
Vitronectin (Vn) FLS adhering to Vn shows higher proliferative ability in response to PDGF. Adhesion to Vn through [47]
  integrin α v downregulates collagenase expression in human FLS  
Tenascin (Tn) FLS synthesize Tn [52]
  RA-FLS bind more strongly to Tn than normal FLS; monoclonal antibodies to integrin β 1 block adhesion [48]
  Rabbit FLS cultured on Tn/Fn mixed substrate show increased expression of collagenase, stromelysin, [53]
  the 92 kDa gelatinase, and c-fos  
Hyaluronan (HA) Synthesized by FLS, degraded by macrophage-like lining cells [54]
  HA inhibits proliferation of FLS [55]
Decorin Modulates MMP-1 gene expression of rabbit FLS when present on the substrate with Vn or Fn fragment [56]
Perlecan Involved in adhesion and growth of FLS [57]
Collagen type I FLS adhering to collagen type I show higher proliferative ability in response to PDGF. Adhesion to [47]
  collagen type I through integrin β 1 downregulates the collagenase expression in human FLS  
Collagen type IV Synthesized by FLS [58]
  RA-FLS bind more strongly to collagen type IV than normal FLS [48]
  monoclonal antibodies to integrin β 1 block adhesion [59]
  Degraded by MMP-2, MT-MMP [60]
  Degraded by matrilysin [61]
  1. CS-1, connecting sequence 1; ED-A, extra domain-A; MMP, matrix metalloproteinase; MT, membrane type; PDGF, platelet derived growth factor; RA, rheumatoid arthritis.