Fibroblast biology Signals targeting the synovial fibroblast in arthritis

Table 4 Direct cell-cell interactions between fibroblasts and other cell types

Cell type	Effect	Reference
Macrophage	Direct transfer (of FITC-dextran, mannose BSA gold) from macrophages to fibroblasts	[62,63]
Neutrophil	Neutrophil adhesion to fibroblasts is increased by PMA treatment of neutrophils and by IL-1α	[64]
	or TNF-α treatment of fibroblasts
	Fibroblasts provide directional guidance to adhering neutrophils	[65]
	PAF and IL-8 enhance neutrophil adhesion to and motility of adhered neutrophils along	[66]
	fibroblasts, respectively, in an integrin β₂ dependent process
Lymphocyte	Fibroblasts synthesize IL-1α, IL-1β, IL-6 and ICE	[67]
	Fibroblast mediated synthesis of collagen type I and type III is decreased	[68]
Eosinophil	Activated eosinophils adhere to fibroblasts: this adhesion is inhibited with RGDS	[69]
Mast cell	Formation of mast pseudopods and their translocation to fibroblast surface	[70]
	Mast cell stimulates fibroblast proliferation after cell-cell contact in an IL-4 dependent manner	[71]
	Gap junctions between the mast cell and fibroblast are possible	[72]
Osteoblast-like cells	Osteoblast-like cells stimulate fibroblast proliferation (regulation of osteoprogenitor cell	[73]
	proliferation?)

BSA, bovine serum albumen; ICE, interleukin-1β -converting enzyme; IL, interleukin; FITC, fluorescein isothiocyanate; PAF, platelet-activating factor; PMA, phorbol myristate acetate; RGDS, arginyl-glycyl-aspartyl-serine; TNF, tumor necrosis factor.

ISSN: 1478-6362