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Table 4 Direct cell-cell interactions between fibroblasts and other cell types

From: Fibroblast biology Signals targeting the synovial fibroblast in arthritis

Cell type Effect Reference
Macrophage Direct transfer (of FITC-dextran, mannose BSA gold) from macrophages to fibroblasts [62,63]
Neutrophil Neutrophil adhesion to fibroblasts is increased by PMA treatment of neutrophils and by IL-1α [64]
  or TNF-α treatment of fibroblasts  
  Fibroblasts provide directional guidance to adhering neutrophils [65]
  PAF and IL-8 enhance neutrophil adhesion to and motility of adhered neutrophils along [66]
  fibroblasts, respectively, in an integrin β2 dependent process  
Lymphocyte Fibroblasts synthesize IL-1α, IL-1β, IL-6 and ICE [67]
  Fibroblast mediated synthesis of collagen type I and type III is decreased [68]
Eosinophil Activated eosinophils adhere to fibroblasts: this adhesion is inhibited with RGDS [69]
Mast cell Formation of mast pseudopods and their translocation to fibroblast surface [70]
  Mast cell stimulates fibroblast proliferation after cell-cell contact in an IL-4 dependent manner [71]
  Gap junctions between the mast cell and fibroblast are possible [72]
Osteoblast-like cells Osteoblast-like cells stimulate fibroblast proliferation (regulation of osteoprogenitor cell [73]
  1. BSA, bovine serum albumen; ICE, interleukin-1β -converting enzyme; IL, interleukin; FITC, fluorescein isothiocyanate; PAF, platelet-activating factor; PMA, phorbol myristate acetate; RGDS, arginyl-glycyl-aspartyl-serine; TNF, tumor necrosis factor.